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Laboratorium voor Toxicologie en Farmacologie (KULeuven)
www.farm.kuleuven.ac.be/toxico/index.html

Info  Persons | Publications 
English name: Laboratory for Toxicology and Pharmacology
Parent institute: KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen (KULeuven), more
Address:
O. & N.2
Herestraat 49B 922
3000 Leuven
Belgium
 
Type: Scientific

Persons (9)  Top | Publications 

Abstract:
The laboratory for Toxicology and Pharmacology of the KU Leuven University conducts research on substances foreign to the body (among which toxins) and studies the safety aspects and the composition of foodstuffs. At the request of the Belgian Court of Justice, the laboratory also performs forensic toxicological analyses and conducts research on biological samples (including post mortem) and confiscated products.

With regard to marine research, the laboratory focuses on the discovery and characterisation of toxins (peptides and small organic molecules) present in poison glands or organs of marine species such as jellyfish, sea anemones and Conus snails. The research group aims to further concentrate on this topic in the future. Within this context, the main challenge is to combine state-of-the-art analytical techniques (for example chromatography, mass spectrometry and sequencing) in order to link proteomics with transcriptomics and functional studies.

The laboratory for Toxicology and Pharmacology also participated in the MAREX-project (2010-2014 - EU FP7) on exploring marine resources for bioactive compounds.

Publications (51)  Top | Persons 
    ( 46 peer reviewed ) split up filter
  • Peer reviewed article García-Fernández, R.; Peigneur, S.; Pons, T.; Alvarez, C.; González, L.; Chávez, M.A.; Tytgat, J. (2016). The Kunitz-type protein ShPI-1 inhibits serine proteases and voltage-gated potassium channels. Toxins 8(4): 110. dx.doi.org/10.3390/toxins8040110, more
  • Peer reviewed article Kopljar, I.; Grottesi, A.; de Block, T.; Rainier, J.D.; Tytgat, J.; Labro, A.J.; Snyders, D.J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology 107: 160-167. https://hdl.handle.net/10.1016/j.neuropharm.2016.03.010, more
  • Peer reviewed article Lebbe, E.K.M.; Ghequire, M.G.K.; Peigneur, S.; Mille, B.G.; Devi, P.; Ravichandran, S.; Waelkens, E.; D'Souza, L.; De Mot, R.; Tytgat, J. (2016). Novel conopeptides of largely unexplored Indo Pacific Conus sp. Mar. Drugs 14(11): 18 pp. https://hdl.handle.net/10.3390/md14110199, more
  • Peer reviewed article Lebbe, E.K.M.; Tytgat, J. (2016). In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds. Journal of Venomous Animals and Toxins Including Tropical Diseases 22: 15 pp. https://hdl.handle.net/10.1186/s40409-016-0083-6, more
  • Peer reviewed article Martínez-Morales, E.; Kopljar, I.; Rainier, J.D.; Tytgat, J.; Snyders, D.J.; Labro, A.J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon 120: 57-60. https://hdl.handle.net/10.1016/j.toxicon.2016.07.017, more
  • Peer reviewed article Jukic, M.; Frlan, R.; Chan, F.; Kirby, R.; Madge, D.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D. (2015). Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators. Med. Chem. Res. 24(6): 2366-2380. dx.doi.org/10.1007/s00044-014-1300-x, more
  • Peer reviewed article Sintsova, O.; Chausova, V.; Gladkikh, I.; Isaeva, M.; Tabakmaher, V.; Monastyrnaya, M.; Leychenko, E.; Pislyagin, E.; Menchinskaya, E.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). New antihistamine Kunitz-type polypeptides of the sea anemones, Heteractis crispa and Stichodactyla mertensii. The FEBS Journal 282(Suppl. 1): 140-141, more
  • Peer reviewed article Zelepuga, E.; Gladkikh, I.; Monastyrnaya, M.; Sintsova, O.; Tabakmaher, V.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). The sea anemone Heteractis crispa - a source of potential pharmacological agents. The FEBS Journal 282(Suppl. 1): 322-323, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Wijesekara, I.; Tytgat, J. (2014). Conotoxins targeting nicotinic acetylcholine receptors: an overview. Mar. Drugs 12(5): 2970-3004. dx.doi.org/10.3390/md12052970, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Mille, B.G.; Devi, P; Ravichandran, S; Lescrinier, E.; Waelkens, E.; D'Souza, L; Herdewijn, P.; Tytgat, J. (2014). Discovery of a new subclass of alpha-conotoxins in the venom of Conus australis. Toxicon 91: 145-154. http://dx.doi.org/10.1016/j.toxicon.2014.08.074, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P; Ravichandran, S; D'Souza, L; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. Toxicon 91: 170-171. dx.doi.org/10.1016/j.toxicon.2014.08.023, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P.; Ravichandran, S.; Lescrinier, E.; Ulens, C.; Waelkens, E.; D'Souza, L.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. 289(14): 9573-9583. https://dx.doi.org/10.1074/jbc.M114.556175, more
  • Peer reviewed article Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J. (2014). Action of Clathrodin and analogues on voltage-gated sodium channels. Mar. Drugs 12(4): 2132-2143. dx.doi.org/10.3390/md12042132, more
  • Peer reviewed article Peigneur, S.; Tytgat, J. (2014). When cone snails and spiders meet: design of selective and potent sodium channel inhibitors. Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.022, more
  • Peer reviewed article Rodriguez, A; Salceda, E; Garateix, G; Zaharenko, J; Peigneur, S.; Lopez, O; Pons, T; Richardson, M; Diaz, M; Hernandez, Y; Standker, L; Tytgat, J.; Soto, E (2014). A novel sea anemone peptide that inhibits acid-sensing ion channels. Peptides (New York, NY : 1980) 53: 3-12. dx.doi.org/10.1016/j.peptides.2013.06.003, more
  • Peer reviewed article Tytgat, J. (2014). Sea anemone toxins: from lab bench discovery to commercial drugs? Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.021, more
  • Peer reviewed article Wijesekara, I.; Peigneur, S.; Devi, P; Ravichandran, S; Lebbe, E.; Mille, B.; D'Souza, L; Tytgat, J. (2014). Isolation and characterization of novel conopeptides from Conus amadis that target voltage-gated sodium channels. Toxicon 91: 184-184. dx.doi.org/10.1016/j.toxicon.2014.08.056, more
  • Peer reviewed article Zidar, N.; Jakopin, Z.; Madge, D.; Chan, F.; Tytgat, J.; Peigneur, S.; Dolenc, M.; Tomasic, T.; Ilas, J.; Masic, L.; Kikelj, D. (2014). Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators. Eur. J. Med. Chem. 74: 23-30. dx.doi.org/10.1016/j.ejmech.2013.12.034, more
  • Peer reviewed article Bergeron, Z.L.; Chun, J.B.; Baker, M.R.; Sandall, D.W.; Peigneur, S.; Yu, P.Y.C.; Thapa, P.; Milisen, J.W.; Tytgat, J.; Livett, B.G.; Bingham, J.P. (2013). A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile-The pharmacological importance of post-translational modifications. Peptides (New York, NY : 1980) 49: 145-158. dx.doi.org/10.1016/j.peptides.2013.09.004, more
  • Peer reviewed article Cassoli, J.; Verano-Braga, T.; Oliveira, J.; Montandon, G.; Cologna, C.T.; Peigneur, S.; Pimenta, A.; Kjeldsen, F.; Roepstorff, P.; Tytgat, J.; de Lima, M. (2013). The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide. J. Proteomics 87: 89-102. dx.doi.org/10.1016/j.jprot.2013.05.022, more
  • Peer reviewed article Kendel, Y.; Melaun, C.; Kurz, A.; Nicke, A.; Peigneur, S.; Tytgat, J.; Wunder, C.; Mebs, D.; Kauferstein, S. (2013). Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. Toxins 5(5): 1043-1050. dx.doi.org/10.3390/toxins5051043, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.; Tytgat, J.; Snyders, D.J. (2013). The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J. Gen. Physiol. 141(3): 359-369. dx.doi.org/10.1085/jgp.201210890, more
  • Peer reviewed article Orts, D.J.B.; Peigneur, S.; Madio, B.; Cassoli, J.S.; Montandon, G.G.; Pimenta, A.M.C.; Bicudo, J.E.P.W.; Freitas, J.C.; Zaharenko, A.J.; Tytgat, J. (2013). Biochemical and electrophysiological characterization of two sea anemone Type 1 Potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar. Drugs 11(3): 655-679. dx.doi.org/10.3390/md11030655, more
  • Peer reviewed article Orts, D.J.B.; Moran, Y.; Cologna, C.T.; Peigneur, S.; Madio, B.; Praher, D.; Quinton, L.; De Pauw, E.; Bicudo, J.E.P.W.; Tytgat, J.; de Freitas, J.C. (2013). BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker. The FEBS Journal 280(19): 4839-4852. dx.doi.org/10.1111/febs.12456, more
  • Peer reviewed article Peigneur, S.; Van Der Haegen, A.; Möller, C.; Waelkens, E.; Diego-García, E.; Marí, F.; Naudé, R.; Tytgat, J. (2013). Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (New York, NY : 1980) 41: 8-16. https://hdl.handle.net/10.1016/j.peptides.2012.07.002, more
  • Peer reviewed article Tomašic, T.; Hartzoulakis, B.; Zidar, N.; Chan, F.; Kirby, R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. (2013). Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators. Journal of Chemical Information and Modeling 53(12): 3223-3232. https://hdl.handle.net/10.1021/ci400505e, more
  • Peer reviewed article Gladkikh, I.; Monastyrnaya, M.; Leychenko, E.; Zelepuga, E.; Chausova, V.; Isaeva, M.; Anastyuk, S.; Andreev, Y.; Peigneur, S.; Tytgat, J.; Kozlovkaya, E. (2012). Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa. Mar. Drugs 10(7): 1545-1565. hdl.handle.net/10.3390/md10071545, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2012). Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin Gambierol. Toxicon 60(2): 150-151. dx.doi.org/10.1016/j.toxicon.2012.04.111, more
  • Peer reviewed article Peigneur, S.; Lescrinier, E.; Moller, C.; Mari, F.; Beress, L.; Tytgat, J. (2012). A natural point mutation reveals target promiscuity of toxins isolated from the sea anemone Anthopleura elegantissima. Biophys. J. 102(3, Supplement 1): 658A-658A, more
  • Peer reviewed article Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2012). A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 26(12): 5141-5151. hdl.handle.net/10.1096/fj.12-218479, more
  • Peer reviewed article Stevens, M.; Peigneur, S.; Dyubankova, N.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Design of bioactive peptides from naturally occurring µ-conotoxin structures. J. Biol. Chem. 287(37): 31382-31392. dx.doi.org/10.1074/jbc.M112.375733, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Dyubankova, N.; Moller, C.; Mari, F.; Diego-García, E.; Naude, R.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity. Peptides (New York, NY : 1980) 34(1): 106-113. dx.doi.org/10.1016/j.peptides.2011.10.026, more
  • Peer reviewed article Cuypers, E.; Peigneur, S.; Debaveye, S.; Shiomi, K.; Tytgat, J. (2011). TRPV1 channel as new target for marine toxins: Example of gigantoxin I, a sea anemone toxin acting via modulation of the PLA2 pathway. Acta Chim. Slov. 58(4): 735-741, more
  • Peer reviewed article Peigneur, S.; Billen, B.; Derua, R.; Waelkens, E.; Debaveye, S.; Béress, L.; Tytgat, J. (2011). A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem. Pharmacol. 82(1): 81-90. https://hdl.handle.net/10.1016/j.bcp.2011.03.023, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Tytgat, J. (2011). Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. The FEBS Journal 278(18): 3408-3418. dx.doi.org/10.1111/j.1742-4658.2011.08264.x, more
  • Peer reviewed article Billen, B.; Debaveye, S.; Béress, L.; Garateixand, A.; Tytgat, J. (2010). Phyla- and subtype-selectivity of CgNa, a Na+ channel toxin from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea. Front. Pharmacol. 1: 133. hdl.handle.net/10.3389/fphar.2010.00133, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; Cuypers, E.; Johnson, H.W.B.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2009). A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc. Natl. Acad. Sci. U.S.A. 106(24): 9896-9901. hdl.handle.net/10.1073/pnas.0812471106, more
  • Peer reviewed article Cuypers, E.; Abdel-Mottaleb, Y.; Kopljar, I.; Rainier, J.; Raes, A.L.; Snyders, D.J.; Tytgat, J. (2008). Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon 51(6): 974-983. dx.doi.org/10.1016/j.toxicon.2008.01.004, more
  • Peer reviewed article Bosmans, F.; Tytgat, J. (2007). Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. Toxicon 49(4): 550-560. dx.doi.org/10.1016/j.toxicon.2006.11.029, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. (2007). TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem. Biophys. Res. Commun. 361(1): 214-217. dx.doi.org/10.1016/j.bbrc.2007.07.009, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2007). Corrigendum to "Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels" [FEBS Lett. 580 (2006) 5728-5732]. FEBS Lett. 581(8): 1699. dx.doi.org/10.1016/j.febslet.2007.03.036, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2006). Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett. 580(24): 5728-5732. dx.doi.org/10.1016/j.febslet.2006.09.030, more
  • Peer reviewed article Kauferstein, S.; Huys, I.; Kuch, U.; Melaun, C.; Tytgat, J.; Mebs, D. (2004). Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon 44(5): 539-548, more
  • Peer reviewed article Fan, C.X.; Chen, X.K.; Zhang, C.; Wang, L.X.; Duan, K.L.; He, L.L.; Cao, Y.; Liu, S.Y.; Zhong, M.N.; Ulens, C.; Tytgat, J.; Chen, J.S.; Chi, C.W.; Zhou, Z. (2003). A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J. Biol. Chem. 278(15): 12624-12633, more
  • Peer reviewed article Bosmans, F.; Aneiros, A.; Tytgat, J. (2002). The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett. 532(1-2): 131-134. dx.doi.org/10.1016/S0014-5793(02)03653-0, more
  • Peer reviewed article Goudet, C.; Ferrero, T.; Galàn, L.; Artiles, A.; Batista, C.F.V.; Possani, L.D.; Alvarez, J.; Aneiros, A.; Tytgat, J. (2001). Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels. Br. J. Pharmacol. 134(6): 1195-1206. dx.doi.org/10.1038/sj.bjp.0704361, more
  • Kopljar, I.; Peigneur, S.; Snyders, D.J.; Tytgat, J. (2014). The mechanism of action of microalgal toxins interacting with Nav and Kv channels, in: Rossini, G.P. (Ed.) Toxins and biologically active compounds from microalgae: Volume 2. Biological effects and risk management. pp. 3-34, more
  • Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2013). Sea anemone toxins: insecticides and painkillers of the future?, in: Mees, J. et al. (Ed.) Marine biotechnology in the European research area: Challenges and opportunities for Europe. Final CSA MarineBiotech Conference. Royal Flemish Academy of Belgium for Science and the Arts, Brussels, Belgium, 11-12 March 2013. VLIZ Special Publication, 64: pp. 7, more
  • Tytgat, J. (2009). Expectancies of a toxicologist: from sudden poisoning to miraculous discovery, in: Mees, J. et al. (Ed.) VLIZ Young Scientists' Day, Brugge, Belgium 6 March 2009: book of abstracts. VLIZ Special Publication, 41: pp. 14, more
  • Tytgat, J. (2008). Toxines van kwallenen zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Prijs Dr. E. Delcroix 2007 - 11 april 2008, Oostende. [S.n.]: [s.l.]. 1 presentation [52 Slides] pp., more
  • Tytgat, J. (2007). Toxines van kwallenen zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Katholieke Universiteit Leuven. Faculteit Farmaceutische Wetenschappen. Laboratorium Toxicologie: Leuven. 23 pp., more

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