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Mr Defoirdt, Tom
orcid.org/0000-0002-7446-2246, orcid
www.researcherid.com/rid/A-5120-2009, researcherid

Institute  Top | Institute | Publications | Project 
    Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierlijk Productie; Laboratorium voor Aquacultuur en Artemia Reference Center (ARC), more
    Direct contact at institute:
    E-mail:
 

Previous institute  Top | Institute | Publications | Project 
    Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Biochemische en microbiële technologie; Laboratorium voor Microbiële Ecologie en Technologie (LabMET), more

Project  Top | Institute | Publications | Project 
  • Disruption of quorum sensing in order to prevent and cure aquatic disease, more

Publications (55)  Top | Institute | Publications | Project 
    ( 50 peer reviewed ) split up
  • Peer reviewed article Asanka Gunasekara, R.A.Y.S.; Defoirdt, T.; Rekecki, A.; Decostere, A.; Cornelissen, M.; Sorgeloos, P.; Bossier, P.; Van Den Broeck, W. (2012). Light and transmission electron microscopy of Vibrio campbellii infection in gnotobiotic Artemia franciscana and protection offered by a yeast mutant with elevated cell wall glucan. Vet. Microbiol. 158(3-4): 337-343. hdl.handle.net/10.1016/j.vetmic.2012.02.025, more
  • Peer reviewed article Baruah, K.; Ho Phuong Pham Duy Phong ; Norouzitallab, P.; Defoirdt, T.; Bossier, P. (2015). The gnotobiotic brine shrimp (Artemia franciscana) model system reveals that the phenolic compound pyrogallol protects against infection through its prooxidant activity. Free Radic. Biol. Med. 89: 593-601. dx.doi.org/10.1016/j.freeradbiomed.2015.10.397, more
  • Peer reviewed article Brackman, G.; Defoirdt, T.; Miyamoto, C.; Bossier, P.; Van Calenbergh, S.; Nelis, H.J.; Coenye, T. (2008). Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiol. 8. dx.doi.org/10.1186/1471-2180-8-149, more
  • Peer reviewed article Crab, R.; Avnimelech, Y.; Defoirdt, T.; Bossier, P.; Verstraete, W. (2007). Nitrogen removal techniques in aquaculture for a sustainable production. Aquaculture 270(1-4): 1-14. dx.doi.org/10.1016/j.aquaculture.2007.05.006, more
  • Peer reviewed article Crab, R.; Lambert, A.; Defoirdt, T.; Bossier, P.; Verstraete, W. (2010). The application of bioflocs technology to protect brine shrimp (Artemia franciscana) from pathogenic Vibrio harveyi. J. Appl. Microbiol. 109(5): 1643-1649. dx.doi.org/10.1111/j.1365-2672.2010.04791.x, more
  • Peer reviewed article Dang, T.V.C.; Nguyen, V.H.; Dierckens, K.; Defoirdt, T.; Boon, N.; Sorgeloos, P.; Bossier, P. (2009). Novel approach of using homoserine lactone-degrading and poly-beta-hydroxybutyrate-accumulating bacteria to protect Artemia from the pathogenic effects of Vibrio harveyi. Aquaculture 291(1-2): 23-30. dx.doi.org/10.1016/j.aquaculture.2009.03.009, more
  • Peer reviewed article De Schryver, P.; Crab, R.; Defoirdt, T.; Boon, N.; Verstraete, W. (2008). The basics of bio-flocs technology: the added value for aquaculture. Aquaculture 277(3-4): 125-137. dx.doi.org/10.1016/j.aquaculture.2008.02.019, more
  • Peer reviewed article De Schryver, P.; Defoirdt, T.; Sorgeloos, P. (2014). Early mortality syndrome outbreaks: a microbial management issue in shrimp farming? PLoS Pathog. 10(4): -. dx.doi.org/10.1371/journal.ppat.1003919, more
  • Peer reviewed article Defoirdt, T.; Boon, N.; Bossier, P.; Verstraete, W. (2004). Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture. Aquaculture 240(1-4): 69-88. dx.doi.org/10.1016/j.aquaculture.2004.06.031, more
  • Peer reviewed article Defoirdt, T.; Bossier, P.; Sorgeloos, P.; Verstraete, W. (2005). The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana. Environ. Microbiol. 7(8): 1239-1247, more
  • Peer reviewed article Defoirdt, T.; Crab, R.; Wood, T.K.; Sorgeloos, P.; Verstraete, W.; Bossier, P. (2006). Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates. Appl. Environ. Microbiol. 72(9): 6419-6423. dx.doi.org/10.1128/AEM.00753-06, more
  • Peer reviewed article Defoirdt, T.; Halet, D.; Sorgeloos, P.; Bossier, P.; Verstraete, W. (2006). Short-chain fatty acids protect gnotobiotic Artemia franciscana from pathogenic Vibrio campbellii. Aquaculture 261(2): 804-808. dx.doi.org/10.1016/j.aquaculture.2006.06.038, more
  • Peer reviewed article Defoirdt, T.; Halet, D.; Vervaeren, H.; Boon, N.; Van de Wiele, T.; Sorgeloos, P.; Bossier, P.; Verstraete, W. (2007). The bacterial storage compound poly-ß-hydroxybutyrate protects Artemia franciscana from pathogenic Vibrio campbellii. Environ. Microbiol. 9(2): 445-452. dx.doi.org/10.1111/j.1462-2920.2006.01161.x, more
  • Defoirdt, T.; Halet, D.; Sorgeloos, P.; Bossier, P.; Verstraete, W. (2007). The bacterial storage compound PHB protects Artemia franciscana from pathogenic Vibrio campbellii, in: Mees, J. et al. (Ed.) VLIZ Young Scientists' Day, Brugge, Belgium 2 March 2007: book of abstracts. VLIZ Special Publication, 39: pp. 30, more
  • Peer reviewed article Defoirdt, T.; Miyamoto, C.M.; Wood, T.K.; Meighen, E.A.; Sorgeloos, P.; Verstraete, W.; Bossier, P. (2007). The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR. Environ. Microbiol. 9(10): 2486-2495. dx.doi.org/10.1111/j.1462-2920.2007.01367.x, more
  • Peer reviewed article Defoirdt, T.; Boon, N.; Sorgeloos, P.; Verstraete, W.; Bossier, P. (2007). Alternatives to antibiotics to control bacterial infections: luminescent vibriosis in aquaculture as an example. Trends Biotechnol. 25(10): 472-479. dx.doi.org/10.1016/j.tibtech.2007.08.001, more
  • Peer reviewed article Defoirdt, T.; Verstraete, W.; Bossier, P. (2008). Luminescence, virulence and quorum sensing signal production by pathogenic Vibrio campbellii and Vibrio harveyi isolates. J. Appl. Microbiol. 104(5): 1480-1487. dx.doi.org/10.1111/j.1365-2672.2007.03672.x, more
  • Peer reviewed article Defoirdt, T.; Boon, N.; Sorgeloos, P.; Verstraete, W.; Bossier, P. (2008). Quorum sensing and quorum quenching in Vibrio harveyi: lessons learned from in vivo work. ISME J. 2(1): 19-26. dx.doi.org/10.1038/ismej.2007.92, more
  • Defoirdt, T.; Miyamoto, C.M.; Wood, T.K.; Meighen, E.A.; Sorgeloos, P.; Verstraete, W.; Bossier, P. (2009). The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3- butyl-2(5H)-furanone disrupts quorum sensing in Vibrio harveyi by decreasing the DNA-binding activity of the master regulator luxR, in: Mees, J. et al. (Ed.) Book of abstracts: an overview of marine research in Belgium anno 2009. 10th VLIZ Young Scientists' Day. Special edition at the occasion of 10 years VLIZ. VLIZ Special Publication, 43: pp. 48, more
  • Peer reviewed article Defoirdt, T.; Thanh, L.D.; Van Delsen, B.; De Schryver, P.; Sorgeloos, P.; Boon, N.; Bossier, P. (2011). N-acylhomoserine lactone-degrading Bacillus strains isolated from aquaculture animals. Aquaculture 311(1-4): 258-260. dx.doi.org/10.1016/j.aquaculture.2010.11.046, more
  • Peer reviewed article Defoirdt, T.; Benneche, T.; Brackman, G.; Coenye, T.; Sorgeloos, P.; Scheie, A. (2012). A quorum sensing-disrupting brominated thiophenone with a promising therapeutic potential to treat luminescent vibriosis. PLoS One 7(7): e41788. dx.doi.org/10.1371/journal.pone.0041788, more
  • Peer reviewed article Defoirdt, T.; Pande, G.; Baruah, K.; Bossier, P. (2013). The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production. Antimicrob. Agents Chemother. 57(6): 2870-2873. dx.doi.org/10.1128/AAC.00401-13, more
  • Peer reviewed article Defoirdt, T.; Sorgeloos, P. (2012). Monitoring of Vibrio harveyi quorum sensing activity in real time during infection of brine shrimp larvae. ISME J. 6(12): 2314-2319. dx.doi.org/10.1038/ismej.2012.58, more
  • Peer reviewed article Eggermont, M.; Tamanji, A.; Nevejan, N.; Bossier, P.; Sorgeloos, P.; Defoirdt, T. (2014). Stimulation of heterotrophic bacteria associated with wild-caught blue mussel (Mytilus edulis) adults results in mass mortality. Aquaculture 431: 136-138. dx.doi.org/10.1016/j.aquaculture.2014.01.014, more
  • Peer reviewed article Gomez-Gil, B.; Roque, A.; Rotllant, G.; Romalde, L.; Doce, A.; Eggermont, M.; Defoirdt, T. (2016). Photobacterium sanguinicancri sp. nov. isolated from marine animals. Antonie van Leeuwenhoek 109(6): 817-825. dx.doi.org/10.1007/s10482-016-0681-x, more
  • Peer reviewed article Halet, D.; Defoirdt, T.; Van Damme, P.; Vervaeren, H.; Forrez, I.; Van de Wiele, T.; Boon, N.; Sorgeloos, P.; Bossier, P.; Verstraete, W. (2007). Poly-ß-hydroxybutyrate-accumulating bacteria protect gnotobiotic Artemia franciscana from pathogenic Vibrio campbellii. FEMS Microbiol. Ecol. 60(3): 363-369, more
  • Peer reviewed article LeRoux, F.; Wegner, K.; Baker-Austin, C.; Vezzulli, L.; Osorio, C.; Amaro, C.; Ritchie, J.; Defoirdt, T.; Destoumieux-Garzon, D.; Blokesch, M.; Mazel, D.; Jacq, A.; Cava, F.; Gram, L.; Wendling, C.; Strauch, E.; Kirschner, A.; Huehn, S. (2015). The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11-12th March 2015). Front. Microbiol. 6: 830. dx.doi.org/10.3389/fmicb.2015.00830, more
  • Peer reviewed article Li, X.; Yang, Q.; Dierckens, K.; Milton, L; Defoirdt, T. (2014). RpoS and indole signaling control the virulence of Vibrio anguillarum towards gnotobiotic sea bass (Dicentrarchus labrax) larvae. PLoS One 9(10): -. dx.doi.org/10.1371/journal.pone.0111801, more
  • Peer reviewed article Li, X.; Defoirdt, T.; Yang, Q.; Laureau, S.; Bossier, P.; Dierckens, K. (2014). Host-induced increase in larval sea bass mortality in a gnotobiotic challenge test with Vibrio anguillarum. Dis. Aquat. Org. 108(3): 211-216. dx.doi.org/10.3354/dao02722, more
  • Peer reviewed article Li, X.; Bossier, P.; Dierckens, K.; Laureau, S.; Defoirdt, T. (2015). Impact of mucin, bile salts and cholesterol on the virulence of Vibrio anguillarum towards gnotobiotic sea bass (Dicentrarchus labrax) larvae. Vet. Microbiol. 175(1): 44-49. dx.doi.org/10.1016/j.vetmic.2014.10.033, more
  • Peer reviewed article Liu, Y.; De Schryver, P.; Van Delsen, B.; Maignien, L.; Boon, N.; Sorgeloos, P.; Verstraete, W.; Bossier, P.; Defoirdt, T. (2010). PHB-degrading bacteria isolated from the gastrointestinal tract of aquatic animals as protective actors against luminescent vibriosis. FEMS Microbiol. Ecol. 74(1): 196-204. dx.doi.org/10.1111/j.1574-6941.2010.00926.x, more
  • Peer reviewed article Natrah, F.M.I.; Kenmegne, M.M.; Wiyoto, W.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2011). Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Aquaculture 317(1-4): 53-57. dx.doi.org/10.1016/j.aquaculture.2011.04.038, more
  • Peer reviewed article Natrah, F.M.I.; Defoirdt, T.; Sorgeloos, P.; Bossier, P. (2011). Disruption of bacterial cell-to-cell communication by marine organisms and its relevance to aquaculture. Mar. Biotechnol. 13(2): 109-126. dx.doi.org/10.1007/s10126-010-9346-3, more
  • Peer reviewed article Natrah, F.M.I.; Ruwandeepika, H.A.D.; Pawar, S.; Karunasagar, I.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2011). Regulation of virulence factors by quorum sensing in Vibrio harveyi. Vet. Microbiol. 154(1-2): 124-129. dx.doi.org/10.1016/j.vetmic.2011.06.024, more
  • Natrah, F.M.I.; Defoirdt, T.; Mardel, M.; Wiyoto, W.; Sorgeloos, P.; Bossier, P. (2011). Quorum sensing inhibitors from micro-algae commonly used in aquaculture, in: Mees, J. et al. (Ed.) VLIZ Young Marine Scientists' Day, Brugge, Belgium 25 February 2011: book of abstracts. pp. 58, more
  • Peer reviewed article Natrah, F.M.I.; Alam, M.I.; Pawar, S.; Harzevili, A.S.; Nevejan, N.; Boon, N.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2012). The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae. Vet. Microbiol. 159(1-2): 77-82. dx.doi.org/10.1016/j.vetmic.2012.03.014, more
  • Peer reviewed article Niu, Y.; Defoirdt, T.; Rekecki, A.; De Schryver, P.; Van Den Broeck, W.; Dong, S.; Sorgeloos, P.; Boon, N.; Bossier, P. (2012). A method for the specific detection of resident bacteria in brine shrimp larvae. J. microbiol. methods 89(1): 33-37. dx.doi.org/10.1016/j.mimet.2012.02.004, more
  • Peer reviewed article Niu, Y.; Defoirdt, T.; Baruah, K.; Van de Wiele, T.; Dong, L; Bossier, P. (2014). Bacillus sp. LT3 improves the survival of gnotobiotic brine shrimp (Artemia franciscana) larvae challenged with Vibrio campbellii by enhancing the innate immune response and by decreasing the activity of shrimp-associated vibrios. Vet. Microbiol. 173(3-4): 279-288. dx.doi.org/10.1016/j.vetmic.2014.08.007, more
  • Peer reviewed article Pande, G.; Natrah, F.M.I.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2013). The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Vet. Microbiol. 167(3-4): 540-545. dx.doi.org/10.1016/j.vetmic.2013.08.021, more
  • Peer reviewed article Phuoc, L.H.; Defoirdt, T.; Sorgeloos, P.; Bossier, P. (2009). Virulence of luminescent and non-luminescent isogenic vibrios towards gnotobiotic Artemia franciscana larvae and specific pathogen-free Litopenaeus vannamei shrimp. J. Appl. Microbiol. 106(4): 1388-1396. dx.doi.org/10.1111/j.1365-2672.2008.04107.x, more
  • Plovie, A.; Nevejan, N.M.; Defoirdt, T.; Boon, N.; Bossier, P. (2011). Quorum sensing-interference to reduce mortality during blue mussel (Mytilus edulis) larviculture, in: Mees, J. et al. (Ed.) VLIZ Young Marine Scientists' Day, Brugge, Belgium 25 February 2011: book of abstracts. pp. 65, more
  • Peer reviewed article Qi, Z.; Dierckens, K.; Defoirdt, T.; Sorgeloos, P.; Boon, N.; Bao, Z.; Bossier, P. (2009). Effects of feeding regime and probionts on the diverting microbial communities in rotifer Brachionus culture. Aquacult. Int. 17(4): 303-315. dx.doi.org/10.1007/s10499-008-9202-x, more
  • Peer reviewed article Qi, Z.; Dierckens, K.; Defoirdt, T.; Sorgeloos, P.; Boon, N.; Bao, Z.; Bossier, P. (2009). Analysis of the evolution of microbial communities associated with different cultures of rotifer strains belonging to different cryptic species of the Brachionus plicatilis species. Aquaculture 292(1-2): 23-29. dx.doi.org/10.1016/j.aquaculture.2009.03.030, more
  • Peer reviewed article Ruwandeepika, H.; Bhowmick, P.; Karunasagar, I.; Bossier, P.; Defoirdt, T. (2011). Quorum sensing regulation of virulence gene expression in Vibrio harveyi in vitro and in vivo during infection of gnotobiotic brine shrimp larvae. Environmental Microbiology Reports 3(5): 597-602. dx.doi.org/10.1111/j.1758-2229.2011.00268.x, more
  • Peer reviewed article Ruwandeepika, H.; Defoirdt, T.; Bhowmick, P.; Karunasagar, I.; Bossier, P. (2011). Expression of virulence genes in luminescent and nonluminescent isogenic vibrios and virulence towards gnotobiotic brine shrimp (Artemia franciscana). J. Appl. Microbiol. 110(2): 399-406. dx.doi.org/10.1111/j.1365-2672.2010.04892.x, more
  • Peer reviewed article Ruwandeepika, H.; Defoirdt, T.; Bhowmick, P.; Karunasagar, I.; Karunasagar, I.; Bossier, P. (2011). In vitro and in vivo expression of virulence genes in Vibrio isolates belonging to the Harveyi clade in relation to their virulence towards gnotobiotic brine shrimp (Artemia franciscana). Environ. Microbiol. 13(2): 506-517. hdl.handle.net/10.1111/j.1462-2920.2010.02354.x, more
  • Peer reviewed article Ruwandeepika, H.; Jayaweera, T.; Bhowmick, P.; Karunasagar, I.; Bossier, P.; Defoirdt, T. (2012). Pathogenesis, virulence factors and virulence regulation of vibrios belonging to the Harveyi clade. Reviews in Aquaculture 4(2): 59-74. dx.doi.org/10.1111/j.1753-5131.2012.01061.x, more
  • Peer reviewed article Ruwandeepika, H.A.D.; Karunasagar, I.; Bossier, P.; Defoirdt, T. (2015). Expression and quorum sensing regulation of type III secretion system genes of Vibrio harveyi during infection of gnotobiotic brine shrimp. PLoS One 10(12): e0143935. dx.doi.org/10.1371/journal.pone.0143935, more
  • Peer reviewed article Sung, Y.; Dhaene, T.; Defoirdt, T.; Boon, N.; MacRae, T.; Sorgeloos, P.; Bossier, P. (2009). Ingestion of bacteria overproducing DnaK attenuates Vibrio infection of Artemia franciscana larvae. Cell Stress Chap. 14(6): 603-609. dx.doi.org/10.1007/s12192-009-0112-2, more
  • Peer reviewed article Vadstein, O.; Bergh, O.; Gatesoupe, F.J.; Galindo-Villegas, J.; Mulero, V.; Picchietti, S.; Scapigliati, G.; Makridis, P.; Olsen, Y.; Dierckens, K.; Defoirdt, T.; Boon, N.; De Schryver, P.; Bossier, P. (2013). Microbiology and immunology of fish larvae. Reviews in Aquaculture 5(S1): S1-S25. dx.doi.org/10.1111/j.1753-5131.2012.01082.x, more
  • Vanmaele, S.; Defoirdt, T.; Bossier, P. (2012). Aquaculture and immunostimulation through the eyes of Artemia, in: Mees, J. et al. (Ed.) Book of abstracts - VLIZ Young Marine Scientists' Day. Brugge, Belgium, 24 February 2012. VLIZ Special Publication, 55: pp. 104, more
  • Peer reviewed article Vanmaele, S.; Defoirdt, T.; Bossier, P. (2013). Immunostimulation through the eyes of gnotobiotic Artemia franciscana. Fish Shellfish Immunol. 34(6): 1744-1744. hdl.handle.net/10.1016/j.fsi.2013.03.332, more
  • Peer reviewed article Vanmaele, S.; Defoirdt, T.; Cleenwerck, I.; De Vos, P.; Bossier, P. (2015). Characterization of the virulence of Harveyi clade vibrios isolated from a shrimp hatchery in vitro and in vivo, in a brine shrimp (Artemia franciscana) model system. Aquaculture 435: 28-32. dx.doi.org/10.1016/j.aquaculture.2014.09.015, more
  • Peer reviewed article Yang, Q.; Anh, N.D.Q.; Bossier, P.; Defoirdt, T. (2014). Norepinephrine and dopamine increase motility, biofilm formation, and virulence of Vibrio harveyi. Front. Microbiol. 5. dx.doi.org/10.3389/fmicb.2014.00584, more
  • Peer reviewed article Yang, Q.; Defoirdt, T. (2015). Quorum sensing positively regulates flagellar motility in pathogenic Vibrio harveyi. Environ. Microbiol. 17(4): 960-968. dx.doi.org/10.1111/1462-2920.12420, more

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