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Peigneur, Steve

Institute  Top | Institute | Publications 
    KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen; Laboratorium voor Toxicologie en Farmacologie, more
    Function: Marine researcher

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Publications (32)  Top | Institute | Publications 
    ( 30 peer reviewed ) split up
  • Peer reviewed article Bergeron, Z.L.; Chun, J.B.; Baker, M.R.; Sandall, D.W.; Peigneur, S.; Yu, P.Y.C.; Thapa, P.; Milisen, J.W.; Tytgat, J.; Livett, B.G.; Bingham, J.P. (2013). A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile-The pharmacological importance of post-translational modifications. Peptides (New York, NY : 1980) 49: 145-158. dx.doi.org/10.1016/j.peptides.2013.09.004, more
  • Peer reviewed article Cassoli, J.; Verano-Braga, T.; Oliveira, J.; Montandon, G.; Cologna, C.T.; Peigneur, S.; Pimenta, A.; Kjeldsen, F.; Roepstorff, P.; Tytgat, J.; de Lima, M. (2013). The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide. J. Proteomics 87: 89-102. dx.doi.org/10.1016/j.jprot.2013.05.022, more
  • Peer reviewed article Cuypers, E.; Peigneur, S.; Debaveye, S.; Shiomi, K.; Tytgat, J. (2011). TRPV1 channel as new target for marine toxins: Example of gigantoxin I, a sea anemone toxin acting via modulation of the PLA2 pathway. Acta Chim. Slov. 58(4): 735-741, more
  • Peer reviewed article García-Fernández, R.; Peigneur, S.; Pons, T.; Alvarez, C.; González, L.; Chávez, M.A.; Tytgat, J. (2016). The Kunitz-type protein ShPI-1 inhibits serine proteases and voltage-gated potassium channels. Toxins 8(4): 110. dx.doi.org/10.3390/toxins8040110, more
  • Peer reviewed article Gladkikh, I.; Monastyrnaya, M.; Leychenko, E.; Zelepuga, E.; Chausova, V.; Isaeva, M.; Anastyuk, S.; Andreev, Y.; Peigneur, S.; Tytgat, J.; Kozlovkaya, E. (2012). Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa. Mar. Drugs 10(7): 1545-1565. hdl.handle.net/10.3390/md10071545, more
  • Peer reviewed article Jukic, M.; Frlan, R.; Chan, F.; Kirby, R.; Madge, D.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D. (2015). Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators. Med. Chem. Res. 24(6): 2366-2380. dx.doi.org/10.1007/s00044-014-1300-x, more
  • Peer reviewed article Kendel, Y.; Melaun, C.; Kurz, A.; Nicke, A.; Peigneur, S.; Tytgat, J.; Wunder, C.; Mebs, D.; Kauferstein, S. (2013). Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. Toxins 5(5): 1043-1050. dx.doi.org/10.3390/toxins5051043, more
  • Kopljar, I.; Peigneur, S.; Snyders, D.J.; Tytgat, J. (2014). The mechanism of action of microalgal toxins interacting with Nav and Kv channels, in: Rossini, G.P. (Ed.) Toxins and biologically active compounds from microalgae: Volume 2. Biological effects and risk management. pp. 3-34, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Mille, B.G.; Devi, P; Ravichandran, S; Lescrinier, E.; Waelkens, E.; D'Souza, L; Herdewijn, P.; Tytgat, J. (2014). Discovery of a new subclass of alpha-conotoxins in the venom of Conus australis. Toxicon 91: 145-154. http://dx.doi.org/10.1016/j.toxicon.2014.08.074, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P; Ravichandran, S; D'Souza, L; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. Toxicon 91: 170-171. dx.doi.org/10.1016/j.toxicon.2014.08.023, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P.; Ravichandran, S.; Lescrinier, E.; Ulens, C.; Waelkens, E.; D'Souza, L.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. 289(14): 9573-9583. https://dx.doi.org/10.1074/jbc.M114.556175, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Wijesekara, I.; Tytgat, J. (2014). Conotoxins targeting nicotinic acetylcholine receptors: an overview. Mar. Drugs 12(5): 2970-3004. dx.doi.org/10.3390/md12052970, more
  • Peer reviewed article Lebbe, E.K.M.; Ghequire, M.G.K.; Peigneur, S.; Mille, B.G.; Devi, P.; Ravichandran, S.; Waelkens, E.; D'Souza, L.; De Mot, R.; Tytgat, J. (2016). Novel conopeptides of largely unexplored Indo Pacific Conus sp. Mar. Drugs 14(11): 18 pp. https://hdl.handle.net/10.3390/md14110199, more
  • Peer reviewed article Orts, D.J.B.; Moran, Y.; Cologna, C.T.; Peigneur, S.; Madio, B.; Praher, D.; Quinton, L.; De Pauw, E.; Bicudo, J.E.P.W.; Tytgat, J.; de Freitas, J.C. (2013). BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker. The FEBS Journal 280(19): 4839-4852. dx.doi.org/10.1111/febs.12456, more
  • Peer reviewed article Orts, D.J.B.; Peigneur, S.; Madio, B.; Cassoli, J.S.; Montandon, G.G.; Pimenta, A.M.C.; Bicudo, J.E.P.W.; Freitas, J.C.; Zaharenko, A.J.; Tytgat, J. (2013). Biochemical and electrophysiological characterization of two sea anemone Type 1 Potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar. Drugs 11(3): 655-679. dx.doi.org/10.3390/md11030655, more
  • Peer reviewed article Peigneur, S.; Billen, B.; Derua, R.; Waelkens, E.; Debaveye, S.; Béress, L.; Tytgat, J. (2011). A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem. Pharmacol. 82(1): 81-90. https://hdl.handle.net/10.1016/j.bcp.2011.03.023, more
  • Peer reviewed article Peigneur, S.; Lescrinier, E.; Moller, C.; Mari, F.; Beress, L.; Tytgat, J. (2012). A natural point mutation reveals target promiscuity of toxins isolated from the sea anemone Anthopleura elegantissima. Biophys. J. 102(3, Supplement 1): 658A-658A, more
  • Peer reviewed article Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2012). A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 26(12): 5141-5151. hdl.handle.net/10.1096/fj.12-218479, more
  • Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2013). Sea anemone toxins: insecticides and painkillers of the future?, in: Mees, J. et al. (Ed.) Marine biotechnology in the European research area: Challenges and opportunities for Europe. Final CSA MarineBiotech Conference. Royal Flemish Academy of Belgium for Science and the Arts, Brussels, Belgium, 11-12 March 2013. VLIZ Special Publication, 64: pp. 7, more
  • Peer reviewed article Peigneur, S.; Van Der Haegen, A.; Möller, C.; Waelkens, E.; Diego-García, E.; Marí, F.; Naudé, R.; Tytgat, J. (2013). Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (New York, NY : 1980) 41: 8-16. https://hdl.handle.net/10.1016/j.peptides.2012.07.002, more
  • Peer reviewed article Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J. (2014). Action of Clathrodin and analogues on voltage-gated sodium channels. Mar. Drugs 12(4): 2132-2143. dx.doi.org/10.3390/md12042132, more
  • Peer reviewed article Peigneur, S.; Tytgat, J. (2014). When cone snails and spiders meet: design of selective and potent sodium channel inhibitors. Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.022, more
  • Peer reviewed article Rodriguez, A; Salceda, E; Garateix, G; Zaharenko, J; Peigneur, S.; Lopez, O; Pons, T; Richardson, M; Diaz, M; Hernandez, Y; Standker, L; Tytgat, J.; Soto, E (2014). A novel sea anemone peptide that inhibits acid-sensing ion channels. Peptides (New York, NY : 1980) 53: 3-12. dx.doi.org/10.1016/j.peptides.2013.06.003, more
  • Peer reviewed article Sintsova, O.; Chausova, V.; Gladkikh, I.; Isaeva, M.; Tabakmaher, V.; Monastyrnaya, M.; Leychenko, E.; Pislyagin, E.; Menchinskaya, E.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). New antihistamine Kunitz-type polypeptides of the sea anemones, Heteractis crispa and Stichodactyla mertensii. The FEBS Journal 282(Suppl. 1): 140-141, more
  • Peer reviewed article Stas, J.; Kopljar, I.; Labro, A.; Peigneur, S.; Zaharenko, A.J.; Tytgat, J.; Snyders, D.J. (2013). A gating modulator peptide toxin for Shaker-type Kv1 channels derived from the sea anemone Bunodosoma cangicum. Biophys. J. 104(2): 125A-125A, more
  • Peer reviewed article Stevens, M.; Peigneur, S.; Dyubankova, N.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Design of bioactive peptides from naturally occurring µ-conotoxin structures. J. Biol. Chem. 287(37): 31382-31392. dx.doi.org/10.1074/jbc.M112.375733, more
  • Peer reviewed article Tomašic, T.; Hartzoulakis, B.; Zidar, N.; Chan, F.; Kirby, R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. (2013). Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators. Journal of Chemical Information and Modeling 53(12): 3223-3232. https://hdl.handle.net/10.1021/ci400505e, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Tytgat, J. (2011). Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. The FEBS Journal 278(18): 3408-3418. dx.doi.org/10.1111/j.1742-4658.2011.08264.x, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Dyubankova, N.; Moller, C.; Mari, F.; Diego-García, E.; Naude, R.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity. Peptides (New York, NY : 1980) 34(1): 106-113. dx.doi.org/10.1016/j.peptides.2011.10.026, more
  • Peer reviewed article Wijesekara, I.; Peigneur, S.; Devi, P; Ravichandran, S; Lebbe, E.; Mille, B.; D'Souza, L; Tytgat, J. (2014). Isolation and characterization of novel conopeptides from Conus amadis that target voltage-gated sodium channels. Toxicon 91: 184-184. dx.doi.org/10.1016/j.toxicon.2014.08.056, more
  • Peer reviewed article Zelepuga, E.; Gladkikh, I.; Monastyrnaya, M.; Sintsova, O.; Tabakmaher, V.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). The sea anemone Heteractis crispa - a source of potential pharmacological agents. The FEBS Journal 282(Suppl. 1): 322-323, more
  • Peer reviewed article Zidar, N.; Jakopin, Z.; Madge, D.; Chan, F.; Tytgat, J.; Peigneur, S.; Dolenc, M.; Tomasic, T.; Ilas, J.; Masic, L.; Kikelj, D. (2014). Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators. Eur. J. Med. Chem. 74: 23-30. dx.doi.org/10.1016/j.ejmech.2013.12.034, more

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