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Comparative Research on Endocrine Disrupters - Phylogenetic Approach and Common Principles focusing on Androgenic/Antiandrogenic Compounds

More:  Institute 
Reference no: EVK1-CT-2002-00129
Period: October 2002 till September 2005
Status: Completed

Institute  Top 
  • University of Ioannina; Laboratory of Environmental Technology and Pollution Control, more, partner

"The overall goal of COMPRENDO is to improve the understanding of the effects of EDCs on aquatic wildlife and humans, focussing on androgenic and antiandrogenic compounds (AACs). This will help to improve environmental quality standards and also the public health in the Europe.

To this end the key objectives are:

Characterise the human and environmental exposure to AACs;
Determine the impacts of environmentally relevant doses/concentrations of AACs on a wide range of human-relevant models and aquatic species;
Develop new biological effect measures and species-specific critical endpoints, including a molecular screen for genomic effects of AACs;
Identify common principles of AAC action in different species to develop new animal models for extrapolation to human health;
Develop laboratory cultures for suitable aquatic invertebrates and establish their baseline endocrinology;
Characterise the risk originating from AACs in humans and wildlife. "

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