|Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus|
Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Rytik, P.G.; Hentschel, U.; Morschhäuser, J.; Müller, W.E.G. (2003). Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus, in: Müller, W.E.G. (Ed.) Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, : pp. 231-253
In: Müller, W.E.G. (Ed.) (2003). Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISBN 3-540-00968-X. 258 pp., more
In: Müller, W.E.G. (Ed.) Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISSN 1611-6119, more
Alkaloids; Bioactive compounds; Fungi; Sponges; Marine
|Authors|| || Top |
- Bringmann, G.
- Lang, G.
- Mühlbacher, J.
- Schaumann, K.
- Steffens, S.
- Rytik, P.G.
- Hentschel, U.
- Morschhäuser, J.
- Müller, W.E.G.
This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin - its isolation and chemical characterization, and its biological activities. Sorbicillactone A was isolated from a strain of Penicillium chrysogenum cultured from a sample of the Mediterranean sponge Ircinia fasciculate; it possesses a unique bicyclic lactone structure, seemingly derived from sorbicillin. Among the numerous known sorbicillin-derived structures, it is the first found to contain nitrogen and thus the first representative of a novel type of 'sorbicillin alkaloids', apparently originating from a likewise remarkable biosynthesis. Furthermore, the compound exhibits promising activities in several mammalian and viral test systems, in particular a highly selective cytostatic activity against murine leukemic lymphoblasts (L5178y) and the ability to protect human T cells against the cytopathic effects of HIV-1. These properties qualify sorbicillactone A or one of its derivatives for animal and (hopefully) also future therapeutic human trials.