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Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus
Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Rytik, P.G.; Hentschel, U.; Morschhäuser, J.; Müller, W.E.G. (2003). Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus, in: Müller, W.E.G. (Ed.) Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, : pp. 231-253
In: Müller, W.E.G. (Ed.) (2003). Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISBN 3-540-00968-X. 258 pp., more
In: Müller, W.E.G. (Ed.) Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISSN 1611-6119, more

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Keywords
    Alkaloids; Bioactive compounds; Fungi; Sponges; Marine

Authors  Top 
  • Bringmann, G.
  • Lang, G.
  • Mühlbacher, J.
  • Schaumann, K.
  • Steffens, S.
  • Rytik, P.G.
  • Hentschel, U.
  • Morschhäuser, J.
  • Müller, W.E.G.

Abstract
    This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin - its isolation and chemical characterization, and its biological activities. Sorbicillactone A was isolated from a strain of Penicillium chrysogenum cultured from a sample of the Mediterranean sponge Ircinia fasciculate; it possesses a unique bicyclic lactone structure, seemingly derived from sorbicillin. Among the numerous known sorbicillin-derived structures, it is the first found to contain nitrogen and thus the first representative of a novel type of 'sorbicillin alkaloids', apparently originating from a likewise remarkable biosynthesis. Furthermore, the compound exhibits promising activities in several mammalian and viral test systems, in particular a highly selective cytostatic activity against murine leukemic lymphoblasts (L5178y) and the ability to protect human T cells against the cytopathic effects of HIV-1. These properties qualify sorbicillactone A or one of its derivatives for animal and (hopefully) also future therapeutic human trials.

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