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Effects of melophlins on colony formation of Chinese hamster V79 cells and IL-8 production in PMA-stimulated HL-60 cells
Oda, T.; Fujita, A.; Xu, J.; Mochizuki, M.; Ukai, K.; Namikoshi, M. (2007). Effects of melophlins on colony formation of Chinese hamster V79 cells and IL-8 production in PMA-stimulated HL-60 cells. Mar. Drugs 5(1): 1-5
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Cell differentiation; Sponges; Porifera [WoRMS]; Marine

Authors  Top 
  • Oda, T.
  • Fujita, A.
  • Xu, J.
  • Mochizuki, M.
  • Ukai, K.
  • Namikoshi, M.

Abstract
    We have recently isolated four new melophlins P (1), Q (2), R (3), and S (4) together with seven known melophlins A (5), D (6), E (7), G (8), H (9), I (10), and O (11) from two marine sponges of the genus Melophlus collected in Palau. In this study, the influence of these compounds on the colony formation of Chinese hamster V79 cells and the production of IL-8 in PMA-stimulated HL-60 cells were examined. These 11 compounds did not show any effect on IL-8 production. The EC50 values of compounds 2, 3, 4, 5, 7, 9, 10, and 11 against V79 cells were 44.0, 13.3, 16.7, 27.2, 19.8, 8.5, 23.1, and 9.6 ?M, respectively. The linear-chain-type compounds (1, 6, and 8) were not active against V79 cells at 50 ?M. Although the growth inhibitory activity of these melophlins was not remarkable, some structure-activity relationships of these compounds against V79 and murine leukemia L1210 cells were observed.

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