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Manzamenones inhibit T-cell protein tyrosine phosphatase
Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. (2006). Manzamenones inhibit T-cell protein tyrosine phosphatase. Mar. Drugs 4(1): 9-14
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

Available in Authors 

Keywords
    Inhibitors; Plakortis Schulze, 1880 [WoRMS]; Marine

Authors  Top 
  • Wakuda, Y.
  • Kubota, T.
  • Shima, H.
  • Okada, T.
  • Mitsuhashi, S.
  • Aoki, N.
  • Kikuchi, K.
  • Kobayashi, J.

Abstract
    Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

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