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Effects of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated promyelocytic leukemia cell line
Oda, T.; Fujiwara, T.; Liu, H.; Ukai, K.; Mangindaan, R.E.P.; Mochizuki, M.; Namikoshi, M. (2006). Effects of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated promyelocytic leukemia cell line. Mar. Drugs 4(1): 15-21
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

Available in Authors 

Keywords
    Lissoclinum Verrill, 1871 [WoRMS]; Marine

Authors  Top 
  • Oda, T.
  • Fujiwara, T.
  • Liu, H.
  • Ukai, K.
  • Mangindaan, R.E.P.
  • Mochizuki, M.
  • Namikoshi, M.

Abstract
    The effects of seven compounds 1-7, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a dose-dependent manner. Compounds 2 and 5 are structural isomers possessing dimeric structures of trans and cis-orientations, respectively, and showed a very similar activity on the induction of IL-8 levels. Compound 3 and lissoclinotoxin E (4) are also structural isomers having dimeric trans and cis-structures, respectively, but 4 did not induce the IL-8 production. Lissoclibadin 1 (1, trimeric compound) and two monomeric compounds (6 and 7) did not increase the IL-8 level. Therefore, the differences in their structures remarkably affected the IL-8 production activity, the inhibition of cell proliferation, and the survival of HL-60 cells. Lissoclibadin 2 was the most interesting compound of the seven metabolites tested in this study.

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