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Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources
Fahmy, H.; Zjawiony, J.K.; Konoshima, T.; Tokuda, H.; Khan, S.; Khalifa, S. (2006). Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources. Mar. Drugs 4(2): 28-36
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Sarcophyton glaucum (Quoy & Gaimard, 1833) [WoRMS]; Marine

Authors  Top 
  • Fahmy, H.
  • Zjawiony, J.K.
  • Konoshima, T.
  • Tokuda, H.
  • Khan, S.
  • Khalifa, S.

Abstract
    In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O- tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well as the multiplicity of skin tumors per mouse compared to untreated controls.

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