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The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels
Geffeney, S.L.; Ruben, P.C. (2006). The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels. Mar. Drugs 4(3): 143-156
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Neurotoxins; Tetrodotoxin; TTX; Marine

Authors  Top 
  • Geffeney, S.L.
  • Ruben, P.C.

Abstract
    Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.

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