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The estrogen receptor of the gastropod Nucella lapillus: modulation following exposure to an estrogenic effluent?
Castro, L.F.C.; Melo, C.; Guillot, R.; Mendes, I.; Queirós, S.; Lima, D.; Reis-Henriques, M.A.; Santos, M.M. (2007). The estrogen receptor of the gastropod Nucella lapillus: modulation following exposure to an estrogenic effluent? Aquat. Toxicol. 84(4): 465-468. https://dx.doi.org/10.1016/j.aquatox.2007.07.008
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, more
Peer reviewed article  
Available in  Authors 
Keywords
    Estrogens
    Nucella lapillus (Linnaeus, 1758) [WoRMS]
    ANE, France, Brittany, Morbihan Gulf [Marine Regions]
    Marine/Coastal
Author keywords
    prosobranch snails; endocrine disruption; estrogenic chemicals; realtime PCR
Authors  Top 
  • Castro, L.F.C.
  • Melo, C.
  • Guillot, R.
  • Mendes, I.
  • Queirós, S.
  • Lima, D.
  • Reis-Henriques, M.A.
  • Santos, M.M.
Abstract
    The molecular targets of estrogenic endocrine disrupting chemicals have been studied in detail in vertebrates. The lack of basic endocrine knowledge impairs similar approaches for invertebrates. Evidence indicates that the signalling pathways of invertebrates may also be a target of estrogenic chemicals (ECs). In fact, the exposure to effluents containing ECs has been reported to impact mollusc reproduction. Despite the reported estrogen independence of the mollusc nuclear estrogen receptor (ER), its role in EC-induced toxicity has not been investigated in vivo. Therefore, we have cloned the ER of the gastropod Nucella lapillus and evaluated the effects of a mixture of estrogenic chemicals (sewage effluent) on its expression in the ovary. Here, we show that the exposure to a raw domestic/industrial effluent, impact ER expression with a simultaneous reproductive maturation. These results highlight the need to further investigate the role of ER on the reproductive process in prosobranch gastropods and whether this signalling pathway is prone to disruption by ECs.
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