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A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter
Hoover, C.A.; Slattery, M.; Marsh, A.G. (2007). A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Mar. Biotechnol. 9(4): 411-419. dx.doi.org/10.1007/s10126-007-9008-2
In: Marine Biotechnology. Springer-Verlag: New York. ISSN 1436-2228, more
Peer reviewed article

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Keywords
    Gene expression; Genomes; Genomics; Secondary metabolites; Transcriptome; Marine

Authors  Top 
  • Hoover, C.A.
  • Slattery, M.
  • Marsh, A.G.

Abstract
    Secondary metabolites or natural products have been isolated from many marine organisms. These metabolites often have important bioactive functions; however, very little information is available regarding the biosynthesis and regulation of many secondary metabolites. At a time when use of marine-derived metabolites is rapidly expanding in industry and pharmacological fields, a better understanding of the genetic mechanisms controlling secondary metabolite production is necessary. We review the recent development of a novel transcriptome profiling methodology that allows for rapid and high-throughput screening of changes in mRNA sequence pools. The application of genomics-based techniques and the integration of both biochemical and molecular data sets in marine organisms complement ongoing drug discovery efforts.

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