|Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels|In: Toxicon. Elsevier: Oxford. ISSN 0041-0101, more
Animal physiology; Aquatic insects; Biological poisons; Evolution; Insecticides; Marine invertebrates; Neurotoxins; Peptides; Receptors; Toxins; Actiniaria [WoRMS]; Marine
sea anemone; voltage-gated sodium channel; insecticide; toxin; site 3;ATX-II
|Authors|| || Top |
- Bosmans, F.
- Tytgat, J., more
Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.