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Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex König
Regalado, E.L.; Rodríguez, M.; Menéndez, R.; Concepción, Á.A.; Nogueiras, C.; Laguna, A.; Rodríguez, A.A.; Williams, D.E.; Lorenzo-Luaces, P.; Valdés, O.; Hernandez, Y. (2009). Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex König. Mar. Biotechnol. 11(1): 74-80. dx.doi.org/10.1007/s10126-008-9123-8
In: Marine Biotechnology. Springer-Verlag: New York. ISSN 1436-2228, more
Peer reviewed article

Available in Authors 

Keywords
    Thalassia testudinum Banks ex König, 1805 [WoRMS]; Marine

Authors  Top 
  • Regalado, E.L.
  • Rodríguez, M.
  • Menéndez, R.
  • Concepción, Á.A.
  • Nogueiras, C.
  • Laguna, A.
  • Rodríguez, A.A.
  • Williams, D.E.
  • Lorenzo-Luaces, P.
  • Valdés, O.
  • Hernandez, Y.

Abstract
    Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 µg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 µg/cm2) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC50=100 ?g/ml. These results suggest that thalassiolin B is responsible for the skin-regenerating effects of the crude extract of T. testudinum.

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