|Uptake of dieldrin and dieldrin-induced changes in the activities of microsomal liver enzymes of the marine flatfish Pleuronectes platessa L.|
Vink, G.J. (1975). Uptake of dieldrin and dieldrin-induced changes in the activities of microsomal liver enzymes of the marine flatfish Pleuronectes platessa L., in: Koeman, J.H. et al. (Ed.) Sublethal effects of toxic chemicals on aquatic animals. pp. 145-157
In: Koeman, J.H.; Strik, J.J.T.W.A. (Ed.) (1975). Sublethal effects of toxic chemicals on aquatic animals. Elsevier Scientific/Elsevier Scientific Publishing Company: Amsterdam. ISBN 0-44-44139-95. 234 pp., more
Enzymes; Insecticides; Liver; Marine pollution; Musculoskeletal system; Pollution effects; Pleuronectes platessa Linnaeus, 1758 [WoRMS]; Marine
During a 30-day exposure of plaice (P. platessa) to 0.4 µg dieldrin l-1 seawater, an investigation was carried out to study the influence of dieldrin uptake by the liver on the in vitro activities of xenobiotic metabolizing microsomal liver enzymes. It appears that dieldrin suppresses the activity of aminopyrine demethylase, at a steady state level of dieldrin in the liver (5 mg.kg-1, wet weight), which is reached after 2 weeks' exposure. Aniline hydroxylase is not much influenced, although there is some indication that dieldrin temporarily promotes the activity of this enzyme system. However, this was found only once and must be verified in further studies. This enhancement of the activity of aniline hydroxylase coincides with a decrease of the accumulation rate of dieldrin in the liver, which leads to the steady state level. However, the conc of dieldrin in muscle tissue continues to increase during the entire expt, even at a higher accumulation rate, after the steady state level of dieldrin has been reached in the liver.