| one publication added to basket [138085] | Toxicity of Gonyaulax tamarensis var. excavata cells to the brine shrimp Artemia salina
In: Journal of pharmaceutical sciences. American Pharmaceutical Association: Easton, Pa.. ISSN 0022-3549; e-ISSN 1520-6017, more
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| Authors | | Top |
- Betz, J.M.
- Blogoslawski, W.J.
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| Abstract |
Brine shrimp (Artemia salina L.) were exposed to concentrations of live Gonyaulax tamarensis var. excavata cells ranging from 0 to 13,400 cells/ml in unialgal culture. The shrimp ingested the dinoflagellate cells and an LD50 determination was made. The shrimp had a 72-hr LD50 of 1258 G. tamarensis cells/ml, which was calculated to correspond to 73,385 micrograms/kg of body weight. This figure can be compared with an oral LD50 value of 2100 micrograms/kg for the mouse. Since it requires one-tenth as much toxin to kill a mouse (LD50 approximately 0.04 mg) as to kill an Artemia (LD50 approximately 0.4 mg), the whole cell G. tamarensis bioassay is a poor alternative to the current mouse assay. |
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