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Comparative acute toxicity of the first 50 multicentre evaluation of in vitro cytotoxicity chemicals to aquatic non-vertebrates
Calleja, M.C.; Persoone, G.; Geladi, P. (1994). Comparative acute toxicity of the first 50 multicentre evaluation of in vitro cytotoxicity chemicals to aquatic non-vertebrates. Arch. Environ. Contam. Toxicol. 26(1): 69-78
In: Archives of Environmental Contamination and Toxicology. Springer: New York. ISSN 0090-4341, more
Peer reviewed article  

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Keywords
    Aquatic environment; Aquatic organisms; Bacteria; Bioassay; Bioassays; Chemical pollutants; Chemical pollution; Pollutants; Toxicity; Toxicity testing; Toxicity tests; Xenobiotics; Invertebrata; Marine; Brackish water; Fresh water

Authors  Top 
  • Calleja, M.C.
  • Persoone, G., more
  • Geladi, P.

Abstract
    The acute toxicity data of the first 50 chemicals of the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme is compared for three "cyst-based toxicity tests" (Artoxkit M with Artemia salina, Streptoxkit F with Streptocephalus proboscideus, and Rotoxkit F with Brachionus calyciflorus), and two other tests (the Daphnia magna and the Photobacterium phosphoreum Microtox tests) commonly used in ecotoxicology. The difference in sensitivity for the 50 chemicals was as high as 19 orders of magnitude (on a molecular weight basis) between the most and least sensitive species. Generally, a similar toxicity ranking of the 5 test species was found for most of the chemicals and the interspecies correlations were high. Results from Principal Component Analysis (PCA) and cluster analysis indicated that the groupings are not related to a clear and defined chemical structure.

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