IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Printer-friendly version

Influence of pH on the sonolysis of ciprofloxacin: biodegradability, ecotoxicity and antibiotic activity of its degradation products
De Bel, E.; Dewulf, J.; De Witte, B.; Van Langenhove, H.; Janssen, C.R. (2009). Influence of pH on the sonolysis of ciprofloxacin: biodegradability, ecotoxicity and antibiotic activity of its degradation products. Chemosphere 77(2): 291-295. https://hdl.handle.net/10.1016/j.chemosphere.2009.07.033
In: Chemosphere. Elsevier: Oxford. ISSN 0045-6535, more
Peer reviewed article  

Available in  Authors 

Keyword
    Fresh water
Author keywords
    Ultrasonic irradiation; pH; Biodegradability; Antibiotic activity;Pseudokirchneriella subcapitata; Ciprofloxacin

Authors  Top 
  • Van Langenhove, H., more
  • Janssen, C.R., more

Abstract
    The presence of antibiotics in the aquatic environment has raised concerns due to the potential risk for the emergence or persistence of antibiotic resistance. Antibiotics are often poorly degraded in conventional wastewater treatment plants. In this study, sonolysis at 520 kHz and 92 W L(-1) was used for the degradation of the fluoroquinolone antibiotic ciprofloxacin. in a first experiment at pH 7, 57% of the ciprofloxacin (15 mg L(-1)) was degraded after 120 min of ultrasonic irradiation at 25 degrees C. pH proved to be an important parameter determining the degradation rate, since the pseudo first order degradation constant increased almost fourfold when comparing treatment at pH 7 (0.0058 min(-1)) and pH 10 (0.0069 min(-1)) with that at pH 3 (0.021 min(-1)). This effect can be attributed to the degree of protonation of the ciprofloxacin molecule. The BOD/COD ratio of the solutions, which is a measure for their biodegradability, increased from 0.06 to 0.60, 0.17, and 0.18 after 120 min of irradiation depending on the pH (3, 7, and 10, respectively). The solution treated at pH 3 can even be considered readily biodegradable (BOD/COD > 0.4). The antibiotic activity against Escherichia coli (G-) and Bacillus coagulans (G+) of the treated solutions also reduced after sonolysis. The highest decrease was again found when irradiated at pH 3. In contrast, ecotoxicity of the solutions to the alga Pseudokirchneriella subcapitata increased 3- to 10-fold after 20 min of treatment, suggesting the formation of toxic degradation products. The toxicity slowly diminished during further treatment.

All data in IMIS is subject to the VLIZ privacy policy Top | Authors