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A novel method to study diversity and functions of peptides in neuronal networks: peptides of the network underlying male copulation behaviour in the mollusc Lymnaea stagnalis
Van Kesteren, R.E.; Van Golen, F.A.; Li, K.W.; Smit, A.B.; Geraerts, W.P.M. (1995). A novel method to study diversity and functions of peptides in neuronal networks: peptides of the network underlying male copulation behaviour in the mollusc Lymnaea stagnalis. Neth. J. Zool. 45(1-2): 57-63
In: Netherlands Journal of Zoology. E.J. Brill: Leiden. ISSN 0028-2960, more
Peer reviewed article  

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Keyword
    Fresh water

Authors  Top 
  • Van Kesteren, R.E.
  • Van Golen, F.A.
  • Li, K.W.
  • Smit, A.B.
  • Geraerts, W.P.M.

Abstract
    Direct matrix-assisted laser desorption ionization mass spectrometry of neurons and nerves was used to study the diversity, localization and transport of neuropeptides that are produced in the neuronal network that underlies male copulation behavior in the mollusc Lymnaea stagnalis. These studies reveal a large peptide diversity and distinct peptide profiles in different parts of the network, suggesting a complex regulation of copulation behavior. Two peptides, e.g., conopressin and APGWamide, which are co-localized in neurons of the network, are involved in the control of vas deferens activities. Conopressin, which is structurally related to vasopressin, induces muscular contractions of the vas deferens, whereas APWGamide inhibits the conopressin-induced contractions. Together, these peptides may be involved in the modulation of peristaltic movements of the vas deferens.

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