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Schistosoma parasites evoke stress responses in their snail host by a cytokine-like factor interfering with neuro-endocrine mechanisms
De Jong-Brink, M.; Hoek, R.M.; Smit, A.B.; Bergamin-Sassen, M.J.M.; Lageweg, W. (1995). Schistosoma parasites evoke stress responses in their snail host by a cytokine-like factor interfering with neuro-endocrine mechanisms. Neth. J. Zool. 45(1-2): 113-116
In: Netherlands Journal of Zoology. E.J. Brill: Leiden. ISSN 0028-2960, more
Peer reviewed article  

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  • De Jong-Brink, M.
  • Hoek, R.M.
  • Smit, A.B.
  • Bergamin-Sassen, M.J.M.
  • Lageweg, W.

Abstract
    Results obtained with the model Trichobilharzia ocellata-Lymnaea stagnalis confirm the hypothesis that schistosome parasites evoke physiological effects in their snail host-castration and giant growth-by interfering with neuroendocrine systems (NES) regulating the physiological processes concerned. In the haemolymph of the snail host a factor, called schistosomin, was found acting at both the central and the peripheral parts of NES involved in regulation of reproduction and growth. Schistosomin appears to be a host-derived factor, probably released by haemocytes and cells in the connective tissue. It meets the criteria of being a cytokine-like factor, which accounts for its interference with NES. Furthermore, the physiological effects caused by schistosomes in the snail host resemble aspecific stress responses in mammals, e.g. upon a bacterial challenge.

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