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Effect of pacap on LH release and intracellular calcium mobilization in porcine pituitary cells
Hidalgo-Diaz, C.; Gonzalez De Aguilar, J.L.; Martinez-Fuentes, A.J.; Garcia-Navarro, S.; Garcia-Navarro, F. (1995). Effect of pacap on LH release and intracellular calcium mobilization in porcine pituitary cells. Neth. J. Zool. 45(1-2): 166-168
In: Netherlands Journal of Zoology. E.J. Brill: Leiden. ISSN 0028-2960, more
Peer reviewed article  

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  • Hidalgo-Diaz, C.
  • Gonzalez De Aguilar, J.L.
  • Martinez-Fuentes, A.J.
  • Garcia-Navarro, S.
  • Garcia-Navarro, F.

Abstract
    Pituitaty adenylate cyclase-activating polypeptide (PACAP) is sugested to control the activity of pituitary cells. Here we demonstrate that PACAP acts directly on gonadotrope cells increasing LH release, modulating the action of gonadotropin Releasing hormone (GnRH) and inducing mobilization of free cytosolyc calcium ((Ca2+)i). PACAP could play a physiological role in the regulation of the hypothalamicpituitary-gonadal axis.

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