The pituitary transcription factor GFH-1/PIT-1: an evolutionary overview
Vila, V.; Jiménez, O.; Güell, A.; Vallejo, D.; De La Hoya, M.; Burgos, A.; Etxabe, J.; Martinez-Barberà, J.P.; Castrillo, J.L. (1995). The pituitary transcription factor GFH-1/PIT-1: an evolutionary overview. Neth. J. Zool. 45(1-2): 229-234
In: Netherlands Journal of Zoology. E.J. Brill: Leiden. ISSN 0028-2960; e-ISSN 1568-542X, more
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| Authors | | Top |
- Vila, V.
- Jiménez, O.
- Güell, A.
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- Vallejo, D.
- De La Hoya, M.
- Burgos, A.
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- Etxabe, J.
- Martinez-Barberà, J.P.
- Castrillo, J.L.
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| Abstract |
Growth hormone (GH) transcription factor 1 (GHF-1) or pituitary transcription factor 1 (Pit-1) is a pituitary gland-specific homeodomain protain of the POU subclass. POU proteins exert critical developmental and transcriptional functions. Two functional regions, tha DNA binding or POU domain and the transcriptional serine-threonine activation domain (STA) are highly conserved between fishes and primates. However a variability in the length of the STA domain (between 71 and 128 amino acid residues) is found in different species as wel as isoformsgenerated by alternative splicing. |
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