IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Printer-friendly version

Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (Salmo salar)
Tollefsen, K.E.; Meys, J.F.A.; Frydenlund, J.; Stenersen, J. (2002). Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (Salmo salar). Mar. Environ. Res. 54(3-5): 697-701. dx.doi.org/10.1016/S0141-1136(02)00173-3
In: Marine Environmental Research. Applied Science Publishers: Barking. ISSN 0141-1136, more
Peer reviewed article  

Available in Authors 
    VLIZ: Open Repository 280019 [ OMA ]

Keyword
    Marine
Author keywords
    endocrine disrupters; sex steroid-binding proteins; ethynylestradiol;

Authors  Top 
  • Tollefsen, K.E.
  • Meys, J.F.A., more
  • Frydenlund, J.
  • Stenersen, J.

Abstract
    Environmental chemicals may modulate the endocrine system through interaction with plasma sex steroid-binding proteins (SBP) and SBP-regulated processes. Some of these chemicals, which are known to interact with the estrogen receptor (ER), were found to bind competitively to the Atlantic salmon (Salmo salar) SBP and potentially disrupt the endocrine function of these proteins. Furthermore, both weakly acting (di-n-butyl phthalate) and potent estrogen mimics (ethynylestradiol), were able to induce a substantial up-regulation of circulating levels of SBP in vivo. Interestingly, modulation of SBP-levels was found to be a more sensitive endpoint than chemically induced interference with classical ER-mediated mechanisms for weakly acting estrogen mimics like di-(n-butyl) phthalate. Interference with the endocrine function of SBPs may thus introduce a novel mechanism for endocrine disruption, and give additional answers to the question why some weakly acting xenoestrogens are causing "estrogen-like" reproductive disturbances in developing males.

All data in IMIS is subject to the VLIZ privacy policy Top | Authors