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Conotoxins: Molecular and therapeutic targets
Lewis, R.J. (2009). Conotoxins: Molecular and therapeutic targets, in: Fusetani, N. et al. (Ed.) (2009). Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, 46: pp. 45-65. dx.doi.org/10.1007/978-3-540-87895-7_2
In: Fusetani, N.; Kem, W. (Ed.) (2009). Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology, 46. Springer: Berlin. ISBN 978-3-540-87892-6. xiv, 259 pp., more
In: Müller, W.E.G. (Ed.) Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin. ISSN 1611-6119, more

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    Marine

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  • Lewis, R.J.

Abstract
    Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology. A number of conopeptides reduce pain in animal models, and several are now in pre-clinical and clinical development for the treatment of severe pain often associated with diseases such as cancer. Less than 1% of cone snail venom peptides are pharmacologically characterised.

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