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Novel hybrid esterase-haloacid dehalogenase enzyme
Beloqui, A.; Polaina, J.; Vieites, J.M.; Reyes-Duarte, D.; Torres, R.; Golyshina, O.V.; Chernikova, T.N.; Waliczek, A.; Aharoni, A.; Yakimov, M.M.; Timmis, K.N.; Golyshin, P.N.; Ferrer, M. (2010). Novel hybrid esterase-haloacid dehalogenase enzyme. ChemBioChem 11(4): 1975-1978. hdl.handle.net/10.1002/cbic.201000258
In: ChemBioChem. Wiley-VCH: Weinheim. ISSN 1439-4227, more
Peer reviewed article  

Available in  Authors 

Keyword
    Marine
Author keywords
    dehalogenases; esterases; hydrolysis; metagenomes; protein design

Authors  Top 
  • Beloqui, A.
  • Polaina, J.
  • Vieites, J.M.
  • Reyes-Duarte, D.
  • Torres, R.
  • Golyshina, O.V.
  • Chernikova, T.N.
  • Waliczek, A.
  • Aharoni, A.
  • Yakimov, M.M.
  • Timmis, K.N.
  • Golyshin, P.N., more
  • Ferrer, M.

Abstract
    Promiscuous proteins: The identification and characterization of a wild-type promiscuous hydrolase that efficiently catalyzes the hydrolysis of ester bonds and haloacids in a single protein has been reported. This study has demonstrated the utility of metagenomics to access novel catalytic activities.

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