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Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods
Nishikawa, J.-I.; Mamiya, S.; Kanayama, T.; Nishikawa, T.; Shiraishi, F.; Horiguchi, T. (2004). Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. Environ. Sci. Technol. 38(23): 6271-6276. hdl.handle.net/10.1021/es049593u
In: Environmental Science and Technology. American Chemical Society: Easton. ISSN 0013-936X, more
Peer reviewed article  

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Keywords
    Imposex; Organotin compounds; Tributyltin; Gastropoda [WoRMS]; Marine

Authors  Top 
  • Nishikawa, J.-I.
  • Mamiya, S.
  • Kanayama, T.
  • Nishikawa, T.
  • Shiraishi, F.
  • Horiguchi, T.

Abstract
    Organotin compounds released from antifouling paints, such as tributyltin (TBT) and triphenyltin (TPT), are potent inducers of imposex (a superimposition of male genital tracts, such as penis and vas deferens, on females) in marine gastropods. Little is known about the induction mechanism of gastropod imposex. Here, we show that organotins bind the human retinoid X receptors (hRXRs) with high affinity and that injection of 9-cis retinoic acid (RA), the natural ligand of hRXRs, into females of the rock shell (Thais clavigera) induces the development of imposex. Cloning of the RXR homologue from T. clavigera revealed that the ligand-binding domain of rock shell RXR was very similar to vertebrate RXR and bound to both 9-cis RA and to organotins. These suggest that RXR plays an important role in inducing the development of imposex, namely, the differentiation and growth of male genital tracts in female gastropods.

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