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Intersex condition and molecular markers of endocrine disruption in relation with burdens of emerging pollutants in thicklip grey mullets (Chelon labrosus) from Basque estuaries (South-East Bay of Biscay)
Bizarro, C.; Ros, O.; Vallejo, A.; Prieto, A.; Etxebarria, N.; Cajaraville, M.P.; Ortiz-Zarragoitia, M. (2014). Intersex condition and molecular markers of endocrine disruption in relation with burdens of emerging pollutants in thicklip grey mullets (Chelon labrosus) from Basque estuaries (South-East Bay of Biscay). Mar. Environ. Res. 96: 19-28. hdl.handle.net/10.1016/j.marenvres.2013.10.009
In: Marine Environmental Research. Applied Science Publishers: Barking. ISSN 0141-1136, more
Peer reviewed article  

Available in Authors 

Keywords
    Chelon labrosus (Risso, 1827) [WoRMS]; Pisces [WoRMS]; Marine
Author keywords
    Endocrine disrupting chemicals; Intersex; Vitellogenin; Aromatase cyp19a1b; Chelon labrosus; Bile analytes; Water chemistry; Bay of Biscay; Fish

Authors  Top 
  • Bizarro, C.
  • Ros, O.
  • Vallejo, A.
  • Prieto, A.
  • Etxebarria, N.
  • Cajaraville, M.P.
  • Ortiz-Zarragoitia, M.

Abstract
    Endocrine disrupting chemicals (EDCs) interfere with the functioning of the endocrine system, causing reproductive and developmental disturbances in aquatic wildlife. Appearance of intersex gonads and elevated plasma levels of vitellogenin in male fish are well known biomarkers of exposure to xenoestrogenic EDCs. In the present study, intersex condition and transcription levels of vtg and cyp19a1b were assessed in five thicklip grey mullet populations from the Basque coast (Bay of Biscay). Levels of EDCs (estrogenic hormones, polycyclic musks, bisphenol-A, phthalates, alkylphenols and pesticides) were determined in water and fish bile. Intersex gonads were observed in three out of five mullet populations. Vtg and cyp19a1b were up-regulated in mullet populations with relatively higher EDCs load. Phthalates and pesticides were the most abundant EDCs in bile, followed by alkylphenols, musks, bisphenol-A and estrogenic hormones. Statistically significant correlations were found between concentrations of individual and total EDCs in bile and water samples and transcription levels of vtg and cyp19a1b.

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