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Coral aquaculture to support drug discovery
Leal, M.C.; Calado, R.; Sheridan, C.; Alimonti, A.; Osinga, R. (2013). Coral aquaculture to support drug discovery. Trends Biotechnol. 31(10): 555-561.
In: Trends in Biotechnology. Elsevier: Amsterdam. ISSN 0167-7799, more
Peer reviewed article  

Available in  Authors 
    VLIZ: Open Repository 258042 [ OMA ]

Author keywords
    Cnidaria; biomass supply; bioactive compounds; microbiota; economicfeasibility

Authors  Top 
  • Leal, M.C.
  • Calado, R.
  • Sheridan, C., more
  • Alimonti, A.
  • Osinga, R.

    Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline.

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