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Chemistry of the nudibranch Aldisa andersoni: structure and biological activity of phorbazole metabolites
Nuzzo, G.; Ciavatta, M.L.; Kiss, R.; Mathieu, V.; Leclercqz, H.; Manzo, E.; Villani, G.; Mollo, E.; Lefranc, F.; D'Souza, L.; Gavagnin, M.; Cimino, G. (2012). Chemistry of the nudibranch Aldisa andersoni: structure and biological activity of phorbazole metabolites. Mar. Drugs 10(8): 1799-1811. http://dx.doi.org/10.3390/md10081799
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Aldisa andersoni Gosliner & Behrens, 2004 [WoRMS]; Nudibranchia [WoRMS]; Marine
Author keywords
    Aldisa andersoni; nudibranch mollusc; structural elucidation;feeding-deterrence; growth inhibitory assays

Authors  Top 
  • Nuzzo, G.
  • Ciavatta, M.L.
  • Kiss, R., more
  • Mathieu, V., more
  • Leclercqz, H.
  • Manzo, E.
  • Villani, G.
  • Mollo, E.
  • Lefranc, F.
  • D'Souza, L.
  • Gavagnin, M.
  • Cimino, G.

Abstract
    The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.

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