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Luminescent threat: toxicity of light stick attractors used in pelagic fishery
Franco de Oliveira, T.; Medeiros da Silva, A.L.; Alves de Moura, R.; Bagattini, R.; Falcão de Oliveira, A.X.; Gennari de Medeiros, M.H.; Di Mascio, P.; de Arruda Campos, I.P.; Barretto, F.P.; Bechara, E.J.H.; de Melo Loureiro, A.P. (2014). Luminescent threat: toxicity of light stick attractors used in pelagic fishery. NPG Scientific Reports 4( 5359): 11. hdl.handle.net/10.1038/srep05359
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322, more
Peer reviewed article  

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Keyword
    Marine

Authors  Top 
  • Franco de Oliveira, T.
  • Medeiros da Silva, A.L.
  • Alves de Moura, R.
  • Bagattini, R.
  • Falcão de Oliveira, A.X.
  • Gennari de Medeiros, M.H.
  • Di Mascio, P.
  • de Arruda Campos, I.P.
  • Barretto, F.P.
  • Bechara, E.J.H.
  • de Melo Loureiro, A.P.

Abstract
    Light sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an improper use of LS contents on the skin. Given the scarce information regarding LS toxicity, the effects of LS solutions in cell cultures were evaluated herein. Loss of viability, cell cycle changes and DNA fragmentation were observed in HepG2 cell line and skin fibroblasts. A non-cytotoxic LS concentration increased the occurrence of the mutagenic lesion 1,N6-edAdo in HepG2 DNA by three-fold. Additionally, in vitro incubations of spent LS contents with DNA generated dGuo-LS adducts, whose structure elucidation revealed the presence of a reactive chlorinated product. In conclusion, the LS contents were found to be highly cyto- and genotoxic. Our data indicate an urgent need for LS waste management guidelines and for adequate information regarding toxic outcomes that may arise from human exposure.

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