IMIS | Flanders Marine Institute

Flanders Marine Institute

Platform for marine research


Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Printer-friendly version

Environmental heat stress induces epigenetic transgenerational inheritance of robustness in parthenogenetic Artemia model
Norouzitallab, P.; Baruah, K.; Vandegehuchte, M.B.; Van Stappen, G.; Catania, F; Vanden Bussche, J.; Vanhaecke, L.; Sorgeloos, P.; Bossier, P. (2014). Environmental heat stress induces epigenetic transgenerational inheritance of robustness in parthenogenetic Artemia model. FASEB J. 28(8): 3552-3563.
In: The FASEB Journal. Federation of American Societies for Experimental Biology: Bethesda, Md.. ISSN 0892-6638, more
Peer reviewed article  

Available in  Authors 
    VLIZ: Open Repository 311452 [ OMA ]

Author keywords
    heat shock protein 70; DNA methylation; histone modification; stressresistance; heritability

Authors  Top 
  • Norouzitallab, P., more
  • Baruah, K., more
  • Vandegehuchte, M.B., more
  • Van Stappen, G., more
  • Catania, F
  • Vanden Bussche, J., more
  • Vanhaecke, L., more
  • Sorgeloos, P., more
  • Bossier, P., more

    The notion that phenotypic traits emerging from environmental experiences are heritable remains under debate. However, the recent report of nonmendelian transgenerational epigenetic inheritance, i.e., the inheritance of traits not determined by the DNA sequence, might make such a phenomenon plausible. In our study, by carrying out common garden experiments, we could provide clear evidences that, on exposure to nonlethal heat shocks, a parental population of parthenogenetic (all female) Artemia (originating from one single female) experiences an increase in levels of Hsp70 production, tolerance toward lethal heat stress, and resistance against pathogenic Vibrio campbellii. Interestingly, these acquired phenotypic traits were transmitted to three successive generations, none of which were exposed to the parental stressor. This transgenerational inheritance of the acquired traits was associated with altered levels of global DNA methylation and acetylated histones H3 and H4 in the heat-shocked group compared to the control group, where both the parental and successive generations were reared at standard temperature. These results indicated that epigenetic mechanisms, such as global DNA methylation and histones H3 and H4 acetylation, have particular dynamics that are crucial in the heritability of the acquired adaptive phenotypic traits across generations.

All data in IMIS is subject to the VLIZ privacy policy Top | Authors