IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Printer-friendly version

In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells
Lefranc, F.; Nuzzo, G; Hamdy, A; Fakhr, I; Banuls, L.M.Y.; Van Goietsenoven, G.; Villani, G; Mathieu, V.; van Soest, R; Kiss, R.; Ciavatta, L (2013). In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells. J. Nat. Prod. 76(9): 1541-1547. dx.doi.org/10.1021/np400107t
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington, DC, etc.. ISSN 0163-3864, more
Peer reviewed article  

Available in Authors 
    VLIZ: Open Repository 274936 [ OMA ]

Keywords
    Diacarnus erythraeanus Kelly-Borges & Vacelet, 1995 [WoRMS]; Marine

Authors  Top 
  • Lefranc, F.
  • Nuzzo, G
  • Hamdy, A
  • Fakhr, I
  • Banuls, L.M.Y.
  • Van Goietsenoven, G.
  • Villani, G
  • Mathieu, V.
  • van Soest, R
  • Kiss, R.
  • Ciavatta, L

Abstract
    Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 mu M, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.

All data in IMIS is subject to the VLIZ privacy policy Top | Authors