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Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach
Liaw, C.-C.; Chen, P.-C.; Shih, C.-J.; Tseng, S.-P.; Lai, Y.-M.; Hsu, C.-H.; Dorrestein, P.C.; Yang, Y.-L. (2015). Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach. NPG Scientific Reports 5(12856): 11 pp. http://hdl.handle.net/10.1038/srep12856
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, more
Peer reviewed article  

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Keyword
    Marine

Authors  Top 
  • Liaw, C.-C.
  • Chen, P.-C.
  • Shih, C.-J.
  • Tseng, S.-P.
  • Lai, Y.-M.
  • Hsu, C.-H.
  • Dorrestein, P.C.
  • Yang, Y.-L.

Abstract
    A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the marine bacterium Vibrio sp. QWI-06 by an integrated approach using imaging mass spectroscopy and molecular networking, as well as conventional bioactivity-guided fractionation and isolation. The structure-activity relationship of vitroprocines against Acinetobacter baumannii is proposed. In addition, feeding experiments with 13C-labeled precursors indicated that a pyridoxal 5'-phosphate-dependent mechanism is involved in the biosynthesis of vitroprocines. Elucidation of amino-polyketide derivatives from a species of marine bacteria for the first time demonstrates the potential of this integrated metabolomics approach to uncover marine bacterial biodiversity.

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