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Anti-tumor natural products isolated from marine organisms
Kitagawa, I.; Kobayashi, M. (1989). Anti-tumor natural products isolated from marine organisms. Gan to Kagaku Ryoho = Japanese Journal of Cancer and Chemotherapy 16(1): 1-8
In: Gan to Kagaku Ryoho = Japanese Journal of Cancer and Chemotherapy. Cancer and Chemotherapy Publishing Company: Tokyo. ISSN 0385-0684, more
Peer reviewed article  

Available in  Authors 

    Cytotoxicity; Marine
Author keywords
    Marine natural products; Anti-tumor activity; Marine sponge; Tunicate; Bryozoan

Authors  Top 
  • Kitagawa, I.
  • Kobayashi, M.

    Marine organisms comprise over half a million species. Due to their unusual living environment as compared with terrestrial organisms, marine organisms produce a variety of metabolic substances which often have various unprecedented chemical structures. In recent years, an increasing number of marine natural products have been reported to exhibit various biological activities such as antimicrobial, physiological, and pharmacological ones. Some metabolites have also been noted by their significant toxicities. The effort to find out anti-tumor substances from marine organisms has been also undertaken in recent years, and several novel compounds (e.g. peptide, polyether, alkaloid, prostanoid etc.), with anti-tumor activities, have been isolated from marine sponges, octocorals, marine algae, tunicates, nudibranchs, bryozoans, and so on. In this article, those chemically clarified anti-tumor compounds isolated from marine organisms were reviewed.

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