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Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata
Damonte, E.; Neyts, J.; Pujol, C.A.; Snoeck, R.; Andrei, G.; Ikeda, S.; Witvrouw, M.; Reymen, D.; Haines, H.; Matulewicz, M.C.; Cerezo, A.; Coto, C.E.; Declercq, E. (1994). Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. Biochem. Pharmacol. 47(12): 2187-2192. dx.doi.org/10.1016/0006-2952(94)90254-2
In: Biochemical Pharmacology. Pergamon Press: London; New York. ISSN 0006-2952, more
Peer reviewed article  

Available in Authors 

Keyword
    Marine
Author keywords
    SULFATED POLYMERS; ANTIVIRAL; HIV; HCMV; HSV; INFLUENZA VIRUS

Authors  Top 
  • Damonte, E.
  • Neyts, J.
  • Pujol, C.A.
  • Snoeck, R.
  • Andrei, G.
  • Ikeda, S.
  • Witvrouw, M.
  • Reymen, D.
  • Haines, H.
  • Matulewicz, M.C.
  • Cerezo, A.
  • Coto, C.E.
  • Declercq, E.

Abstract
    The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption.

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