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Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentia genitrix
Bartik, K.; Braekman, J.C.; Daloze, D.; Stoller, C.; Huysecom, J.; Van de Vyver, G.; Ottinger, R. (1987). Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentia genitrix. Can. J. Chem. = J. Can. Chim. 65(9): 2118-2121. dx.doi.org/10.1139/v87-352
In: Canadian Journal of Chemistry = Journal Canadien de Chimie. National Research Council: Ottawa, Canada. ISSN 0008-4042, more
Peer reviewed article  

Available in Authors 

Keyword
    Marine

Authors  Top 
  • Bartik, K.
  • Braekman, J.C., more
  • Daloze, D.
  • Stoller, C.
  • Huysecom, J.
  • Van de Vyver, G.
  • Ottinger, R.

Abstract
    Three new bis-indole alkaloids, topsentin-A (1), -B1 (2), and -B2 (3) have been isolated from the Mediterranean sponge Topsentia genitrix and their structure determined by spectroscopic methods. These compounds are weakly toxic for fish and for dissociated cells of the freshwater sponge Ephydatia fluviatilis and thus might be partially responsible for the chemical defense of the sponge.

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