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Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro
Osterhaus, A.D.M.E.; Groen, J.; De Clercq, E. (1987). Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro. Antivir. Res. 7(4): 221-226. dx.doi.org/10.1016/0166-3542(87)90030-1
In: Antiviral Research. Elsevier: Amsterdam; New York. ISSN 0166-3542, more
Peer reviewed article  

Available in Authors 

Keyword
    Marine
Author keywords
    Phocid herpesvirus 1; Seal herpesvirus; Antiviral compound

Authors  Top 
  • Osterhaus, A.D.M.E.
  • Groen, J.
  • De Clercq, E.

Abstract
    From a selection of 25 antiviral compounds with specific anti-herpes activity or broad-spectrum antiviral properties, two compounds, namely (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil, appeared particularly effective in inhibiting the cytopathogenicity of seal herpesvirus (phocid herpesvirus 1).

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