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Live-food mediated drug delivery as a tool for disease treatment in larviculture: 2. A case study with European seabass
Chair, M.; Romdhane, M.S.; Dehasque, M.; Nelis, H.; De Leenheer, A.P.; Sorgeloos, P. (1991). Live-food mediated drug delivery as a tool for disease treatment in larviculture: 2. A case study with European seabass. Spec. Publ. Eur. Aquacult. Soc. 15: 412-414
In: Special Publication European Aquaculture Society. European Aquaculture Society: Bredene. ISSN 0774-0689, more

Also published as
  • Chair, M.; Romdhane, M.S.; Dehasque, M.; Nelis, H.; De Leenheer, A.P.; Sorgeloos, P. (1991). Live-food mediated drug delivery as a tool for disease treatment in larviculture: 2. A case study with European seabass, in: (1991). IZWO Coll. Rep. 21(1991). IZWO Collected Reprints, 21: pp. chapter 6, more

Available in Authors 
    VLIZ: Open Repository 2805 [ OMA ]

Keywords
    Antibiotics; Aquaculture techniques; Disease control; Fish culture; Fish larvae; Food additives; Food organisms; Dicentrarchus labrax (Linnaeus, 1758) [WoRMS]; Marine

Authors  Top 
  • Chair, M.
  • Romdhane, M.S.
  • Dehasque, M., more
  • Nelis, H.
  • De Leenheer, A.P.
  • Sorgeloos, P., more

Abstract
    The purpose of this study is to investigate the possibility of oral delivery of the antibiotics Trimethoprim (TMP) and Sulfamethoxazole (SMX) to marine fish larvae through incorporation of these antibiotics into the live food organism Artemia. SMX and TMP were selected for their wide range action against gram negative pathogenic bacteria and because of their limited solubility in seawater. Ormetoprim-Sulfadimethoxine (brand name Romet-30) is a new combination of a similar antimicrobial drug used in aquaculture. Diseased penaeid larvae fed Romet-30 through the food chain exhibited greater survival than the untreated ones. In an earlier study Verpraet have described a technique for bioencapsulating high doses of more than 500 mu g TMP + SMX per gram dry weight (DW) Artemia nauplii. In this study we have used 2-month-old European seabass (Dicentrarchus labrax) larvae that were fed with TMP + SMX - bioencapsulated Artemia nauplii.

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