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Structural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide
Kolsi, R.B.A.; Fakhfakh, J.; Krichen, F.; Jribi, I.; Chiarore, A.; Patti, F.P.; Blecker, C.; Allouche, N.; Belghithi, H.; Belghith, K. (2016). Structural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide. Carbohydrate Polymers 151: 511-522. https://hdl.handle.net/10.1016/j.carbpol.2016.05.098
In: Carbohydrate Polymers. Elsevier SCI Ltd: Oxford. ISSN 0144-8617; e-ISSN 1879-1344, more
Peer reviewed article  

Available in  Authors 

Keyword
    Marine
Author keywords
    Marine angiosperm; Sulfated polysaccharide; LC-ESI-MS/MS analysis; NMRspectroscopy; Antihypertensive properties

Authors  Top 
  • Kolsi, R.B.A.
  • Fakhfakh, J.
  • Krichen, F.
  • Jribi, I.
  • Chiarore, A.
  • Patti, F.P., more
  • Blecker, C.
  • Allouche, N.
  • Belghithi, H.
  • Belghith, K.

Abstract
    A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and antihypertensive properties of this polysaccharide.The CNSP consisted mainly of sulfate (23.17%), total sugars (54.90%), galactose (44.89%), mannose (17.30%), arabinose (12.05%), xylose (9.18%), maltose (1.07%) and uronic acid (11.03%) with low water activity (0.49). CNSP had an XRD pattern that was typical for a semi-crystalline polymer with homogeneous structure. It also displayed an important anti-hypertensive activity (IC50 = 0.43 mg ml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL).Overall, the results indicate that CNSP have attractive chemical, functional and biological properties, with a preliminary structural may have a backbone of branched 6-O-sulfated (1 → 4) galactosidic linkages, which can be considered in the future as alternative additive in various foods, cosmetic and pharmaceutical preparations.

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