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Keikipukalides, furanocembrane diterpenes from the Antarctic deep sea octocoral Plumarella delicatissima
Thomas, S.A.L.; von Salm, J.L.; Clark, S.; Ferlita, S.; Nemani, P.; Azhari, A.; Rice, C.A.; Wilson, N.G.; Kyle, D.E.; Baker, B.J. (2018). Keikipukalides, furanocembrane diterpenes from the Antarctic deep sea octocoral Plumarella delicatissima. J. Nat. Prod. 81(1): 117-123. https://hdl.handle.net/10.1021/acs.jnatprod.7b00732
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, more
Peer reviewed article  

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Keyword
    Marine

Authors  Top 
  • Thomas, S.A.L.
  • von Salm, J.L.
  • Clark, S.
  • Ferlita, S.
  • Nemani, P.
  • Azhari, A.
  • Rice, C.A.
  • Wilson, N.G., more
  • Kyle, D.E.
  • Baker, B.J.

Abstract
    During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2–7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

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