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Bioactive compounds from macroalgae in the new millennium: implications for neurodegenerative diseases
Barbosa, M.; Valentão, P.; Andrade, P.B. (2014). Bioactive compounds from macroalgae in the new millennium: implications for neurodegenerative diseases. Mar. Drugs 12(12): 4934-4972. https://hdl.handle.net/10.3390/md12094934
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
Peer reviewed article  

Available in  Authors 
Document type: Scientific report

Keywords
    Pharmacology
    Technology > Biotechnology
Author keywords
    macroalgae; neuroprotection; neurodegeneration; neuroinflammation; oxidative/nitrosative damage; cholinesterase; Alzheimer’s; Parkinson’s

Authors  Top 
  • Barbosa, M.
  • Valentão, P.
  • Andrade, P.B.

Abstract
    Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.

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