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Unguiculin A and ptilomycalins E-H, antimalarial guanidine alkaloids from the marine sponge Monanchora unguiculata
Campos, P.-E.; Wolfender, J.-L.; Queiroz, E.F.; Marcourt, L.; Al-Mourabit, A.; Frederich, M.; Bordignon, A.; De Voogd, N.; Illien, B.; Gauvin-Bialecki, A. (2017). Unguiculin A and ptilomycalins E-H, antimalarial guanidine alkaloids from the marine sponge Monanchora unguiculata. J. Nat. Prod. 80(5): 1404-1410. https://hdl.handle.net/10.1021/acs.jnatprod.6b01079
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, more
Peer reviewed article  

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Keyword
    Marine

Authors  Top 
  • Campos, P.-E.
  • Wolfender, J.-L.
  • Queiroz, E.F.
  • Marcourt, L.
  • Al-Mourabit, A.
  • Frederich, M., more
  • Bordignon, A.
  • De Voogd, N., more
  • Illien, B.
  • Gauvin-Bialecki, A.

Abstract
    Chemical study of the CH2Cl2–MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A and four pentacyclic alkaloids, ptilomycalins E–H, along with four known compounds: crambescidin 800 and crambescidin 359, crambescidic acid, and fromiamycalin. Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E and the mixture of the new ptilomycalins G and H showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F and fromiamycalin exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively.

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