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Phagocytic activity of marine and freshwater bivalves: in vitro exposure of hemocytes to metals (Ag, Cd, Hg and Zn)
Sauvé, S.; Brousseau, P.; Pellerin, J.; Morin, Y.; Senécal, L.; Goudreau, P.; Fournier, M. (2002). Phagocytic activity of marine and freshwater bivalves: in vitro exposure of hemocytes to metals (Ag, Cd, Hg and Zn). Aquat. Toxicol. 58(3-4): 189-200
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, more
Peer reviewed article  
Available in  Authors 
Keywords
    Bivalves
    Chemical elements > Metals
    Cytometry
    Defence mechanisms > Phagocytosis
    Hemocytes
    Hemocytes
    Bivalvia [WoRMS]
    Marine/Coastal; Fresh water
Authors  Top 
  • Sauvé, S., correspondent
  • Brousseau, P.
  • Pellerin, J.
  • Morin, Y.
  • Senécal, L.
  • Goudreau, P.
  • Fournier, M.
Abstract
    We measured non-specific immune function of various bivalves from marine (Cyrtodaria siliqua, Mactromeris polynyma, Mesosdesma arctatum, Mya arenaria, Mya truncata, Mytilus edulis, Serripes groenlandicus, Siliqua costata) and freshwater environments (Dreissena polymorpha and Elliptio complanata). We used flow cytometry to quantify the phagocytosis of fluorescent microspheres by hemocytes exposed in vitro to increasing levels of various metal compounds (AgNO3, CdCl2, CH3HgCl, HgCl2 and ZnCl2). In some species, low doses of mercury (organic and inorganic) and Zn suggest a hormesis-like stimulation of phagocytic activity. At higher levels of exposure, all metals tested induced a significant dose-related inhibition of hemocyte phagocytosis. The species-specific sensitivity of the assay was determined by comparing the in vitro exposure using the metal concentration inducing a 50% suppression (EC50) of the phagocytic activity. Different species expressed different levels of sensitivity. Our results show the variability of the toxic response of different species within a group of similar organisms. It also highlights the need to consider species-species differences in ecotoxicological risk assessment.
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