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Mal de Debarquement syndrome: a retrospective online questionnaire on the influences of gonadal hormones in relation to onset and symptom fluctuation
Mucci, V.; Canceri, J.M.; Brown, R.; Dai, M.; Yakushin, S.B.; Watson, S.; Van Ombergen, A.; Jacquemyn, Y.; Fahey, P.; Van de Heyning, P.H.; Wuyts, F.; Browne, C.J. (2018). Mal de Debarquement syndrome: a retrospective online questionnaire on the influences of gonadal hormones in relation to onset and symptom fluctuation. Frontiers in Neurology 9: 362. https://hdl.handle.net/10.3389/fneur.2018.00362
In: Frontiers in Neurology. FRONTIERS MEDIA SA: Lausanne. ISSN 1664-2295, more
Peer reviewed article  

Available in  Authors 

Author keywords
    Mal de Debarquement syndrome; balance disorder; gonadal hormones; symptom fluctuations; Mal de Debarquement syndrome hormonal profiles; estrogen withdrawal

Authors  Top 
  • Mucci, V.
  • Canceri, J.M.
  • Brown, R.
  • Dai, M.
  • Yakushin, S.B.
  • Watson, S.
  • Van Ombergen, A.
  • Jacquemyn, Y.
  • Fahey, P.
  • Van de Heyning, P.H.
  • Wuyts, F.
  • Browne, C.J.

Abstract
    Mal de Debarquement Syndrome (MdDS) is a condition characterized by a persistent perception of self-motion, in most cases triggered from exposure to passive motion (e.g., boat travel, a car ride, flights). Patients whose onset was triggered in this way are categorized as Motion-Triggered (MT) subtype or onset group. However, the same syndrome can occur spontaneously or after non-motion events, such as childbirth, high stress, surgery, etc. Patients who were triggered in this way are categorized as being of the Spontaneous/Other (SO) subtype or onset group. The underlying pathophysiology of MdDS is unknown and there has been some speculation that the two onset groups are separate entities. However, despite the differences in onset between the subtypes, symptoms are parallel and a significant female predominance has been shown. To date, the role of gonadal hormones in MdDS pathophysiology has not been investigated. This study aimed to evaluate the hormonal profile of MdDS patients, the presence of hormonal conditions, the influence of hormones on symptomatology and to assess possible hormonal differences between onset groups. In addition, the prevalence of migraine and motion sickness and their relation to MdDS were assessed.

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