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Immunostimulant effects of nucleotide isolated from yeast RNA on carp, Cyprinus carpio L.
Sakai, M.; Taniguchi, K.; Mamoto, K.; Ogawa, H.; Tabata, M. (2001). Immunostimulant effects of nucleotide isolated from yeast RNA on carp, Cyprinus carpio L. J. Fish Dis. 24: 433-438
In: Journal of Fish Diseases. Blackwell Science: Oxford; London; Edinburgh; Boston; Melbourne. ISSN 0140-7775, more
Peer reviewed article  

Available in Authors 

Keyword
    Marine

Authors  Top 
  • Sakai, M.
  • Taniguchi, K.
  • Mamoto, K.
  • Ogawa, H.
  • Tabata, M.

Abstract
    Nucleotides from yeast RNA were evaluated for their ability to enhance the non-specific immune responses in carp, Cyprinus carpio. Oral administration of nucleotides to fish daily for 3 days resulted in enhanced responses of phagocytic and nitroblue tetrazolium (NBT) activities in kidney phagocytic cells. This activation of kidney cells was observed for at least 10 days post-treatment. The serum complement and lysozyme activities also increased in fish treated with nucleotides. Further more, the number of Aeromonas hydrophila in nucleotide-treated fish significantly decreased in the blood, kidney and liver after intraperitoneal injection. Thus yeast nucleotides appear to enhance non- specific immune responses in fish.

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