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Vitellogenesis as a biomarker of reproductive disruption by xenobiotics
Kime, D.E.; Nash, J.P.; Scott, A.P. (1999). Vitellogenesis as a biomarker of reproductive disruption by xenobiotics. Aquaculture 177: 345-352
In: Aquaculture. Elsevier: Amsterdam; London; New York; Oxford; Tokyo. ISSN 0044-8486, more
Peer reviewed article  

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  • Kime, D.E.
  • Nash, J.P.
  • Scott, A.P.

    There is increasing evidence that many xenobiotic chemicals can reduce thereproductive capacity of fish through disruption of the endocrine system. Hepaticstimulation of vitellogenesis in male and juvenile fish provides a sensitive indicationof exposure to environmental oestrogens and oestrogenic chemicals. Moreover,perturbations of female vitellogenin levels can provide a useful marker ofdysfunction caused by endocrine disruption at many sites in the reproductive axis.Vitellogenesis can therefore provide a useful indicator of endocrine disruption byxenobiotics. Both inhibition and stimulation of vitellogenesis can have directrepercussions on the reproductive capacity of fish. An important caveat ininterpreting the results of such studies is that they must be related to othercomponents in the reproductive system which may be more sensitive to disruptionand have greater consequences for reproductive success.

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