|Nuclear and membrane steroid receptors and their functions in teleost gonads|
Thomas, P. (2000). Nuclear and membrane steroid receptors and their functions in teleost gonads, in: Norberg, B. et al. (Ed.) Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. pp. 149-156
In: Norberg, B. et al. (Ed.) (2000). Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. Department of Fisheries and Marine Biology, University of Bergen: Bergen. ISBN 82-7461-048-2. 499 pp., more
In: International Symposium on the Reproductive Physiology of Fish. Museo Nacional de Ciencias Naturales, more
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- Thomas, P., correspondent
Gonadal steroids have long been considered of central importance in the regulation of many morphological and physiological changes which occur in teleost gonads during the reproductive cycle. However, until recently only limited information was available on their mechanisms of action in teleost gonads due to a lack of knowledge of the types of steroid hormone receptors present. The classic mechanism of steroid hormone action is genomic, mediated by binding and activation of specific nuclear steroid receptors located in the cytoplasm or nucleus of the target cell which in turn bind to hormone response elements on genes resulting in alterations in their transcription rates. However, evidence has gradually accumulated that steroids can also exert fast, nongenomic actions by binding to specific receptors on the plasma membranes of target cells resulting in changes in ion fluxes or second messenger activation. Both classes of steroid hormone receptors have been recently identified in teleost gonads and gametes. Recent progress in our understanding of the identity, binding characteristics, structure, multiplicity, physiological and toxicological roles of nuclear and membrane estrogen, androgen, progestogen and 11-deoxycorticosteroid receptors in teleost gonads is briefly reviewed in this chapter.