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In-vitro metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver-microsomes of some wildlife species and rat
Murk, A.; Morse, D.; Boon, J.; Brouwer, A. (1994). In-vitro metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver-microsomes of some wildlife species and rat, in: Dauvin, J.-C. et al. (Ed.) Actes de la 4ème Conférence internationale des Polychètes, Angers, France. Mémoires du Muséum national d'Histoire naturelle. Série A, Zoologie, 162: pp. 253-261
In: Dauvin, J.-C.; Laubier, L.; Reish, D.J. (Ed.) (1994). Actes de la 4ème Conférence internationale des Polychètes, Angers, France. Mémoires du Muséum national d'histoire naturelle. Série A, Zoologie, 162. Éditions du Muséum: Paris, France. ISBN 2-85653-214-4. 642 pp., more
In: Mémoires du Muséum national d'Histoire naturelle. Série A, Zoologie. Editions du Muséum: Paris. ISSN 0078-9747, more
Peer reviewed article  

Also published as
  • Murk, A.; Morse, D.; Boon, J.; Brouwer, A. (1994). In-vitro metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver-microsomes of some wildlife species and rat. Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 270: 253-261, more

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Keyword
    Marine

Authors  Top 
  • Murk, A.
  • Morse, D.
  • Boon, J.
  • Brouwer, A.

Abstract
    A qualitative study was performed of the capacity of hepatic microsomes of several wildlife species to metabolize 3,3',4,4'-tetrachlorobiphenyl (TCB). Hepatic microsomes of species environmentally exposed to polychlorinated biphenyls (PCBs): harbour porpoise (Phocoena phocoena), harbour seal (Phoca vitulina), common tern (Sterna hirundo), and hepatic microsomes from species experimentally exposed to PCBs: elder duck (Somateria mollissima), rainbow trout (Salmo gairdneri), flounder (Platichthys flesus), and Wistar rat, were incubated with 14C-labelled TCB ([14C]TCB). The mammals and birds were able to metabolize TCB at a rate that correlated with their ethoxyresorufin-O-deethylase (EROD) activity. No [14C]TCB metabolism was observed in the fish, despite elevated EROD activity in the trout. HPLC analysis of diisopropylether extracts of the microsomal incubations indicated the presence of 4-OH-, 5-OH-, and 6-OH-tetrachlorobiphenyl metabolites and a yet unidentified metabolite. The ratio of the different hydroxy metabolites formed varied for the various species.

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