| one publication added to basket [58788] | A comparative assessment of the adrenotoxic effects of cadmium in two teleost species, rainbow trout, Oncorhynchus mykiss, and yellow perch, Perca flavescens
Lacroix, A.; Hontela, A. (2004). A comparative assessment of the adrenotoxic effects of cadmium in two teleost species, rainbow trout, Oncorhynchus mykiss, and yellow perch, Perca flavescens. Aquat. Toxicol. 67(1): 13-21. http://dx.doi.org/10.1016/j.aquatox.2003.11.010
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, more
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| Keywords |
Biology > Physiology > Endocrinology
Chemical elements > Metals
Cortisol
Fauna > Aquatic organisms > Aquatic animals > Fish
Techniques > In vitro
Oncorhynchus mykiss (Walbaum, 1792) [WoRMS]; Perca flavescens (Mitchill, 1814) [WoRMS]
Marine/Coastal; Brackish water; Fresh water |
| Author keywords |
fish; metals; endocrine toxicity; in vitro; cortisol; signallingpathways |
| Authors | | Top |
- Lacroix, A.
- Hontela, A., correspondent
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| Abstract |
Rainbow trout (Oncorhynchus mykiss) and yellow perch (Perca flavescens) have a different sensitivity to cadmium (Cd) in vivo (troutO.mykiss = 175.6>LC50/EC50P.flavescens = 37.7). Adrenocortical cells of trout were more sensitive than those of perch and Cd had a higher endocrine-disrupting potential and specificity in trout than in perch. However, in both species, Cd had the same effect on ACTH, dbcAMP and pregnenolone-stimulated cortisol secretion, with pregnenolone maintaining cortisol secretion until cell viability was impaired. These results confirm that for both species, Cd interferes in the signalling pathway of cortisol synthesis in a step prior to the pregnenolone formation. Data provided by the present study revealed important differences in vulnerability of adrenal steroidogenesis between rainbow trout and yellow perch. |
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