IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Printer-friendly version

In-vitro biotransformation of chlorinated bornanes (toxaphene) in hepatic microsomes of marine mammals and birds: influence on bioaccumulation and mutagenicity
Boon, J.P.; Helle, M.; Dekker, M.; Sleiderink, H.M.; de Leeuw, J.W.; Klamer, H.J.C.; Govers, B.; Wester, P.; de Boer, J. (1996). In-vitro biotransformation of chlorinated bornanes (toxaphene) in hepatic microsomes of marine mammals and birds: influence on bioaccumulation and mutagenicity. Mém. Mus. natl. hist. nat., Sér. A Zool. 162: 1-6
In: Mémoires du Muséum national d'Histoire naturelle. Série A, Zoologie. Editions du Muséum: Paris. ISSN 0078-9747, more
Peer reviewed article  

Available in Authors 
Document type: Project report

Keyword
    Marine

Authors  Top 
  • Boon, J.P., more
  • Helle, M.
  • Dekker, M.
  • Sleiderink, H.M.
  • de Leeuw, J.W., more
  • Klamer, H.J.C., more
  • Govers, B.
  • Wester, P.
  • de Boer, J., more

Abstract
    The in-vitro capacity of hepatic microsomal preparations to metabolise toxaphene-derived chlorinated bornanes (CHBs) increased in the order sperm whale < whitebeaked dolphin, albatross << harbour seal. The congeners CHB-26 and CHB50 were persistent to oxidative biotransformation. The NCI mass spectra of a mono- and a tri-hydroxy metabolite of CHB-32, and a mono-hydroxy metabolite of CHB-62 were obtained. The number of peaks in the toxaphene residue in tissues of the same animals was inversely related to the in-vitro biotransformation capacity. In the mutatox assay, toxaphene was sometimes directly mutagenic but metabolism did not appear to increase the mutagenicity.

All data in IMIS is subject to the VLIZ privacy policy Top | Authors